Synthesis of some novel 1,2,4-triazole and 1,3,4-oxadiazole derivatives of biological interest

被引：7

作者：

Patil, Bhimagouda S. ^{[1
]}

Krishnamurthy, G. ^{[2
]}

Lokesh, M. R. ^{[2
]}

Shashikumar, N. D. ^{[2
]}

Naik, H. S. Bhojya ^{[3
]}

Latthe, Prashant R. ^{[1
]}

Ghate, Manjunath ^{[4
]}

机构：

[1] Syngene Int Ltd, Bangalore 560100, Karnataka, India

[2] Sahyadri Sci Coll, Dept Chem, Shimoga 577203, India

[3] Kuvempu Univ, Dept Ind Chem, Shimoga 577451, India

[4] Nirma Univ, Inst Pharm, Ahmadabad 382481, Gujarat, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 07期

关键词：

1,2,4]-Triazolo-[1,3,4] oxadiazole; 1,2,4]-Triazolo-[1,3,4] oxadiazole thioethers; 1,2,4]-Triazolo-[1,3,4] oxadiazole arylidines; Bistriazoles and antimicrobial; PHARMACOLOGICAL EVALUATION; HETEROCYCLIC-COMPOUNDS; IN-VITRO; 1,3,4-THIADIAZOLE; ANTIBACTERIAL; DESIGN; BASES; ACID;

D O I：

10.1007/s00044-012-0332-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, a series of novel [1,2,4]-triazolo-[1,3,4]oxadiazole (8), [1,2,4]-triazolo-[1,3,4]oxadiazole thioethers (9a-b), [1,2,4]-triazolo-[1,3,4]oxadiazole arylidines (10a-g), and bis[1,2,4]-triazole (11) derivatives were prepared with the objective of developing better antimicrobial activity. The structures of the compounds were elucidated by spectral analysis. The newly synthesized compounds (8), (9a-b), (10a-g), and (11) were screened for their antimicrobial activity. Among all the tested compounds (10b) shows significant antibacterial activity.

引用

页码：3341 / 3349

页数：9

共 37 条

[11] Coombs GH, 1974, BIOCH PROTOZOOLOGY B, P319
[12] Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents
El Shehry, M. F.
Abu-Hashem, A. A.
El-Telbani, E. M.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (05) : 1906 - 1911
[13] Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring
Foroumadi, Alireza
Emami, Saeed
Mansouri, Shahla
Javidnia, Azita
Saeid-Adeli, Nosratollah
Shirazi, Farshad H.
Shafiee, Abbas
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (07) : 985 - 992
[14] Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles
Holla, BS
Veerendra, B
Shivananda, MK
Poojary, B
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (7-8) : 759 - 767
[15] Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents
Jayashankar, B.
Rai, K. M. Lokanath
Baskaran, N.
Sathish, H. S.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) : 3898 - 3902
[16] Kavali JR, 2003, INT J CHEM RES, V5, P275
[17] Synthesis and antimicrobial study of novel heterocyclic compounds from hydroxybenzophenones
Khanum, SA
Shashikanth, S
Umesha, S
Kavitha, R
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (11) : 1156 - 1162
[18] Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents
Kucukguzel, S. Gueniz
Tatar, Esra
Rollas, Sevim
Sahin, Fikrettin
Gulluce, Medine
De Clercq, Erik
Kabasakal, Levent
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (07) : 893 - 901
[19] Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents
Kumar, G. V. Suresh
Rajendraprasad, Y.
Mallikarjuna, B. P.
Chandrashekar, S. M.
Kistayya, C.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (05) : 2063 - 2074
[20] N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A novel class of potent orally active human NK1 antagonists
Ladduwahetty, T
Baker, R
Cascieri, MA
Chambers, MS
Haworth, K
Keown, LE
MacIntyre, DE
Metzger, JM
Owen, S
Rycroft, W
Sadowski, S
Seward, EM
Shepheard, SL
Swain, CJ
Tattersall, FD
Watt, AP
Williamson, DW
Hargreaves, RJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) : 2907 - 2914

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