Synthesis of some novel 1,2,4-triazole and 1,3,4-oxadiazole derivatives of biological interest

被引：7
作者：
Patil, Bhimagouda S. [1 ]
Krishnamurthy, G. [2 ]
Lokesh, M. R. [2 ]
Shashikumar, N. D. [2 ]
Naik, H. S. Bhojya [3 ]
Latthe, Prashant R. [1 ]
Ghate, Manjunath [4 ]
机构：
[1] Syngene Int Ltd, Bangalore 560100, Karnataka, India
[2] Sahyadri Sci Coll, Dept Chem, Shimoga 577203, India
[3] Kuvempu Univ, Dept Ind Chem, Shimoga 577451, India
[4] Nirma Univ, Inst Pharm, Ahmadabad 382481, Gujarat, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 07期
关键词：
1,2,4]-Triazolo-[1,3,4] oxadiazole; 1,2,4]-Triazolo-[1,3,4] oxadiazole thioethers; 1,2,4]-Triazolo-[1,3,4] oxadiazole arylidines; Bistriazoles and antimicrobial; PHARMACOLOGICAL EVALUATION; HETEROCYCLIC-COMPOUNDS; IN-VITRO; 1,3,4-THIADIAZOLE; ANTIBACTERIAL; DESIGN; BASES; ACID;
D O I：
10.1007/s00044-012-0332-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, a series of novel [1,2,4]-triazolo-[1,3,4]oxadiazole (8), [1,2,4]-triazolo-[1,3,4]oxadiazole thioethers (9a-b), [1,2,4]-triazolo-[1,3,4]oxadiazole arylidines (10a-g), and bis[1,2,4]-triazole (11) derivatives were prepared with the objective of developing better antimicrobial activity. The structures of the compounds were elucidated by spectral analysis. The newly synthesized compounds (8), (9a-b), (10a-g), and (11) were screened for their antimicrobial activity. Among all the tested compounds (10b) shows significant antibacterial activity.
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收藏
页码：3341 / 3349
页数：9
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