Targeted Neonatal Echocardiography-Guided Therapy in Vein of Galen Aneurysmal Malformation: A Report of Two Cases with a Review of Physiology and Approach to Management

被引：16

作者：

Giesinger, R. E. ^{[1
,2
]}

Elsayed, Y. N. ^{[3
,4
]}

Castaldo, M. P. ^{[1
,2
]}

McNamara, P. J. ^{[1
,2
,5
]}

机构：

[1] Hosp Sick Children, Div Neonatol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[3] Hlth Sci Ctr, Div Neonatol, Winnipeg, MB, Canada

[4] Univ Manitoba, Fac Hlth Sci, Winnipeg, MB, Canada

[5] Univ Toronto, Dept Physiol, Toronto, ON, Canada

来源：

AJP REPORTS | 2019年 / 9卷 / 02期

关键词：

vein of Galen malformation; targeted neonatal echocardiography; hemodynamics; PULMONARY-HYPERTENSION; LAMBS;

D O I：

10.1055/s-0039-1688765

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Vein of Galen malformation results in predictable changes in physiology which exist on a continuum. Severe pulmonary hypertension may present as hypoxemia; however, excessive reduction in pulmonary vascular resistance may precipitate progressive pulmonary overcirculation and impaired systemic blood flow. Right ventricular performance and the patency and direction of the ductus arteriosus may play a crucial role in postductal organ perfusion. Physiological stabilization may be complex and variable over time. The utilization of targeted neonatal echocardiography to guide treatment decisions may improve the ability to provide therapy tailored to the specific disease pathophysiology and monitor serially as conditions change. An enhanced approach to physiological stabilization may reduce the risk of unexpected decompensation and allow for thoughtful, controlled endovascular embolization in appropriate candidates.

引用

页码：E172 / E176

页数：5

共 16 条

[1] Metabolism of the right ventricle and the response to hypertrophy and failure [J].

Altin, S. Elissa ;

Schulze, P. Christian .

PROGRESS IN CARDIOVASCULAR DISEASES, 2012, 55 (02) :229-233

[2] The Impact of Integrated Evaluation of Hemodynamics on Management of Preterm Infants with Late-Onset Compromised Systemic Circulation [J].

Amer, Reem ;

Kalash, Reem ;

Seshia, Mary M. ;

Elsayed, Yasser N. .

AMERICAN JOURNAL OF PERINATOLOGY, 2017, 34 (10) :1011-1019

[3] A BLIND, RANDOMIZED COMPARISON OF THE CIRCULATORY EFFECTS OF DOPAMINE AND EPINEPHRINE INFUSIONS IN THE NEWBORN PIGLET DURING NORMOXIA AND HYPOXIA [J].

BARRINGTON, KJ ;

FINER, NN ;

CHAN, WKY .

CRITICAL CARE MEDICINE, 1995, 23 (04) :740-748

[4] Severe pulmonary hypertensive vascular disease in two newborns with aneurysmal vein of Galen [J].

Dahdah, NS ;

Alesseh, H ;

Dahms, B ;

Saker, F .

PEDIATRIC CARDIOLOGY, 2001, 22 (06) :538-541

[5] Echocardiography on neonatal intensive care units in Australia and New Zealand [J].

Evans, N .

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2000, 36 (02) :169-171

[6] Targeted Neonatal Echocardiography Services Need for Standardized Training and Quality Assurance [J].

Finan, Emer ;

Sehgal, Arvind ;

El Khuffash, Afif ;

McNamara, Patrick J. .

JOURNAL OF ULTRASOUND IN MEDICINE, 2014, 33 (10) :1833-1841

[7] Clinical course and medical management of neonates with severe cardiac failure related to vein of Galen malformation [J].

Frawley, GP ;

Dargaville, PA ;

Mitchell, PJ ;

Tress, BM ;

Loughnan, P .

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2002, 87 (02) :F144-F149

[8] Cardiac Findings in the Fetus with Cerebral Arteriovenous Malformation Are Associated with Adverse Outcome [J].

Godfrey, Max E. ;

Tworetzky, Wayne ;

Morash, Donna ;

Friedrnan, Kevin G. .

FETAL DIAGNOSIS AND THERAPY, 2017, 41 (02) :108-114

[9] Utility of Targeted Neonatal Echocardiography in the Management of Neonatal Illness [J].

Harabor, Andrei ;

Soraisham, Amuchou Singh .

JOURNAL OF ULTRASOUND IN MEDICINE, 2015, 34 (07) :1259-1263

[10] The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow [J].

Lakshminrusimha, Satyan ;

Wiseman, Dean ;

Black, Stephen M. ;

Russell, James A. ;

Gugino, Sylvia F. ;

Oishi, Peter ;

Steinhorn, Robin H. ;

Fineman, Jeffrey R. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (03) :H1491-H1497

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