Laboratory evaluation of commercial hyaluronate sodium products

Eight commercial equine products which utilize hyaluronate sodium as the active ingredient were tested by various means of chemical analysis. These laboratory tests revealed a considerable variation among the eight products tested. Hyaluronic acid concentration for one product was labeled as 5 mg/mL; the other 7 products were labeled as containing 10 mg/mL. Protein concentration varied from 3.33 to 13.83 ppm, intrinsic viscosity varied from 246 to 3978 mL/g, kinematic viscosity varied from 10.3 to 30375 centipoise, and molecular weights were from 82,000 to 2,650,000.