Preliminary studies on the chemical characterization and antihyperlipidemic activity of polysaccharide from the brown alga Sargassum fusiforme

被引：61
作者：
Mao, WJ [1 ]
Li, BF [1 ]
Gu, QQ [1 ]
Fang, YC [1 ]
Xing, HT [1 ]
机构：
[1] Ocean Univ China, Inst Marine Drugs & Foods, Qingdao 266003, Peoples R China
来源：
HYDROBIOLOGIA | 2004年 / 512卷 / 1-3期
关键词：
Sargassum fusiforme; polysaccharide; IR spectroscopy; alginate; antihyperlipidemic activity; China;
D O I：
10.1023/B:HYDR.0000020335.46431.ad
中图分类号：
Q17 [水生生物学];
学科分类号：
071004 ;
摘要：
A polysaccharide (SFP) extracted from the brown alga Sargassum fusiforme (Harv.) Setch. was purified by chromatography on DEAE-Sephadex A50 and Sephadex G-100. Studies using paper chromatography (PC), electrophoresis and infrared spectroscopy (IR) indicated that SFP was a kind of alginate with a molecular weight of 16000 and a molar ratio of mannuronic acid (M) to guluronic acid (G) of 2.75. Pharmacological experiments showed that SFP could markedly decrease the content of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) in the serum of experimental hyperlipidemic rats, and significantly increase the level of high density lipoprotein-cholesterol (HDL-C).
引用
收藏
页码：263 / 266
页数：4
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