Emergence and evolution of TP53 mutations are key features of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide

被引：43

作者：

Lode, Laurence ^{[1
,2
,3
,4
]}

Menard, Audrey ^{[2
]}

Flet, Laurent ^{[5
]}

Richebourg, Steven ^{[6
]}

Loirat, Marion ^{[7
]}

Eveillard, Marion ^{[2
]}

Le Bris, Yannick ^{[2
]}

Godon, Catherine ^{[2
]}

Theisen, Olivier ^{[2
]}

Gagez, Anne-Laure ^{[8
]}

Cartron, Guillaume ^{[3
,8
]}

Commes-Maerten, Therese ^{[4
]}

Villemagne, Bruno ^{[9
]}

Luycx, Odile ^{[10
]}

Godmer, Pascal ^{[11
]}

Pellat-Deceunynck, Catherine ^{[12
]}

Soussi, Thierry ^{[13
,14
,15
]}

Bene, Marie C. ^{[2
]}

Delaunay, Jacques ^{[7
,16
]}

Peterlin, Pierre ^{[7
]}

机构：

[1] Montpellier Univ Hosp, Hematol Biol, Montpellier, France

[2] Nantes Univ Hosp, Hematol Biol, Nantes, France

[3] Univ Montpellier, UMR CNRS5235, Montpellier, France

[4] Hop St Eloi, Inst Rech Med Regeneratrice, INSERM, Team Bio2M,INSERM,U1183, Montpellier, France

[5] Nantes Univ Hosp, Pharm Unit, Nantes, France

[6] Hop St Sacrement, Quebec Univ Hosp, Cytogenet, Quebec City, PQ, Canada

[7] Nantes Univ Hosp, Hematol Clin, Nantes, France

[8] Univ Hosp, Dept Hematol, Montpellier, France

[9] CH La Roche Sur Yon, Hematol Clin, La Roche Sur Yon, France

[10] CH Lorient, Hematol Clin, Lorient, France

[11] CH Vannes, Hematol Clin, Vannes, France

[12] Nantes Univ, Angers Univ, CNRS, CRCINA,INSERM, Nantes, France

[13] UPMC Univ Paris 06, Sorbonne Univ, Paris, France

[14] Ctr Rech Cordeliers, INSERM, U4438, Paris, France

[15] Karolinska Inst, CCK, Dept Oncol Pathol, Stockholm, Sweden

[16] Le Confluent, Hematol Dept, Nantes, France

来源：

HAEMATOLOGICA | 2018年 / 103卷 / 04期

关键词：

ACUTE MYELOID-LEUKEMIA;

D O I：

10.3324/haematol.2017.181404

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E143 / E146

页数：4

共 15 条

[1] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[2] Clinical Effect of Point Mutations in Myelodysplastic Syndromes [J].

Bejar, Rafael ;

Stevenson, Kristen ;

Abdel-Wahab, Omar ;

Galili, Naomi ;

Nilsson, Bjoern ;

Garcia-Manero, Guillermo ;

Kantarjian, Hagop ;

Raza, Azra ;

Levine, Ross L. ;

Neuberg, Donna ;

Ebert, Benjamin L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2496-2506

[3] Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia [J].

Cheson, Bruce D. ;

Greenberg, Peter L. ;

Bennett, John M. ;

Lowenberg, Bob ;

Wijermans, Pierre W. ;

Nimer, Stephen D. ;

Pinto, Antonio ;

Beran, Miloslav ;

de Witte, Theo M. ;

Stone, Richard M. ;

Mittelman, Moshe ;

Sanz, Guillermo F. ;

Gore, Steven D. ;

Schiffer, Charles A. ;

Kantarjian, Hagop .

BLOOD, 2006, 108 (02) :419-425

[4] Clonal evolution in myelodysplastic syndromes [J].

da Silva-Coelho, Pedro ;

Kroeze, Leonie I. ;

Yoshida, Kenichi ;

Koorenhof-Scheele, Theresia N. ;

Knops, Ruth ;

van de Locht, Louis T. ;

de Graaf, Aniek O. ;

Massop, Marion ;

Sandmann, Sarah ;

Dugas, Martin ;

Stevens-Kroef, Marian J. ;

Cermak, Jaroslav ;

Shiraishi, Yuichi ;

Chiba, Kenichi ;

Tanaka, Hiroko ;

Miyano, Satoru ;

de Witte, Theo ;

Blijlevens, Nicole M. A. ;

Muus, Petra ;

Huls, Gerwin ;

van der Reijden, Bert A. ;

Ogawa, Seishi ;

Jansen, Joop H. .

NATURE COMMUNICATIONS, 2017, 8

[5] A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q [J].

Fenaux, Pierre ;

Giagounidis, Aristoteles ;

Selleslag, Dominik ;

Beyne-Rauzy, Odile ;

Mufti, Ghulam ;

Mittelman, Moshe ;

Muus, Petra ;

Boekhorst, Peter Te ;

Sanz, Guillermo ;

del Canizo, Consuelo ;

Guerci-Bresler, Agnes ;

Nilsson, Lars ;

Platzbecker, Uwe ;

Luebbert, Michael ;

Quesnel, Bruno ;

Cazzola, Mario ;

Ganser, Arnold ;

Bowen, David ;

Schlegelberger, Brigitte ;

Aul, Carlo ;

Knight, Robert ;

Francis, John ;

Fu, Tommy ;

Hellstrom-Lindberg, Eva .

BLOOD, 2011, 118 (14) :3765-3776

[6] Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study [J].

Germing, U. ;

Lauseker, M. ;

Hildebrandt, B. ;

Symeonidis, A. ;

Cermak, J. ;

Fenaux, P. ;

Kelaidi, C. ;

Pfeilstoecker, M. ;

Noesslinger, T. ;

Sekeres, M. ;

Maciejewski, J. ;

Haase, D. ;

Schanz, J. ;

Seymour, J. ;

Kenealy, M. ;

Weide, R. ;

Luebbert, M. ;

Platzbecker, U. ;

Valent, P. ;

Goetze, K. ;

Stauder, R. ;

Blum, S. ;

Kreuzer, K-A ;

Schlenk, R. ;

Ganser, A. ;

Hofmann, W-K ;

Aul, C. ;

Krieger, O. ;

Kuendgen, A. ;

Haas, R. ;

Hasford, J. ;

Giagounidis, A. .

LEUKEMIA, 2012, 26 (06) :1286-1292

[7] Robustness of Amplicon Deep Sequencing Underlines Its Utility in Clinical Applications [J].

Grossmann, Vera ;

Roller, Andreas ;

Klein, Hans-Ulrich ;

Weissmann, Sandra ;

Kern, Wolfgang ;

Haferlach, Claudia ;

Dugas, Martin ;

Haferlach, Torsten ;

Schnittger, Susanne ;

Kohlmann, Alexander .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2013, 15 (04) :473-484

[8] TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression [J].

Jaedersten, Martin ;

Saft, Leonie ;

Smith, Alexander ;

Kulasekararaj, Austin ;

Pomplun, Sabine ;

Goehring, Gudrun ;

Hedlund, Anette ;

Hast, Robert ;

Schlegelberger, Brigitte ;

Porwit, Anna ;

Hellstrom-Lindberg, Eva ;

Mufti, Ghulam J. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15) :1971-1979

[9] Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia [J].

Landau, Dan A. ;

Carter, Scott L. ;

Stojanov, Petar ;

McKenna, Aaron ;

Stevenson, Kristen ;

Lawrence, Michael S. ;

Sougnez, Carrie ;

Stewart, Chip ;

Sivachenko, Andrey ;

Wang, Lili ;

Wan, Youzhong ;

Zhang, Wandi ;

Shukla, Sachet A. ;

Vartanov, Alexander ;

Fernandes, Stacey M. ;

Saksena, Gordon ;

Cibulskis, Kristian ;

Tesar, Bethany ;

Gabriel, Stacey ;

Hacohen, Nir ;

Meyerson, Matthew ;

Lander, Eric S. ;

Neuberg, Donna ;

Brown, Jennifer R. ;

Getz, Gad ;

Wu, Catherine J. .

CELL, 2013, 152 (04) :714-726

[10] Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion [J].

List, Alan ;

Dewald, Gordon ;

Bennett, John ;

Giagounidis, Aristotle ;

Raza, Azra ;

Feldman, Eric ;

Powell, Bayard ;

Greenberg, Peter ;

Thomas, Deborah ;

Stone, Richard ;

Reeder, Craig ;

Wride, Kenton ;

Patin, John ;

Schmidt, Michele ;

Zeldis, Jerome ;

Knight, Robert .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (14) :1456-1465

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