One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells

被引：43
作者：
Ding, Jun [1 ,2 ]
Chen, Guilin [1 ,3 ]
Chen, Guofang [4 ]
Guo, Mingquan [1 ,3 ]
机构：
[1] Chinese Acad Sci, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 430074, Hubei, Peoples R China
[2] Wuhan Univ, Dept Chem, Key Lab Analyt Chem Biol & Med, Minist Educ, Wuhan 430072, Hubei, Peoples R China
[3] Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan 430074, Hubei, Peoples R China
[4] St Johns Univ, Chem Dept, New York, NY 11439 USA
来源：
PHARMACEUTICS | 2019年 / 11卷 / 03期
关键词：
epirubicin; one-pot synthesis; silver nanoparticle; antitumor; IN-VITRO; POLYMERIC NANOPARTICLES; DELIVERY; SHELL; CORE; AU; ASSAY; VIVO;
D O I：
10.3390/pharmaceutics11030123
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag+ to Ag-0. The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC50) against Hep G2 cells was 1.92 g/mL, indicating a good antitumor property of the nanoparticle at low dosage.
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