The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review

被引：69
|
作者：
Kramer, C. J. H. [1 ]
Vangangelt, K. M. H. [1 ]
van Pelt, G. W. [1 ]
Dekker, T. J. A. [1 ]
Tollenaar, R. A. E. M. [1 ]
Mesker, W. E. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Surg, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2019年 / 173卷 / 01期
关键词：
Breast cancer; Triple-negative breast cancer; Tumour-stroma ratio; Prognosis; Review; DISEASE-FREE SURVIVAL; INDEPENDENT PREDICTOR; PERIOPERATIVE CHEMOTHERAPY; INFILTRATING LYMPHOCYTES; COLORECTAL-CANCER; VALIDATION; EXPRESSION; CARCINOMA; RECURRENCE; RESECTION;
D O I：
10.1007/s10549-018-4987-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PurposeThere is a strong need to improve the prognostication of breast cancer patients in order to prevent over- and undertreatment, especially when considering adjuvant chemotherapy. Tumour stroma characteristics might be valuable in predicting disease progression.MethodsStudies regarding the prognostic value of tumour-stroma ratio (TSR) in breast cancer are evaluated.ResultsA high stromal content is related to a relatively poor prognosis. The most pronounced prognostic effect of this parameter seems to be observed in the triple-negative breast cancer (TNBC) subtype.ConclusionsTSR assessment might represent a simple, fast and reproducible prognostic factor at no extra costs, and could possibly be incorporated into routine pathological diagnostics. Despite these advantages, a robust clinical validation of this parameter has yet to be established in prospective studies.
引用
收藏
页码：55 / 64
页数：10
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