Recommendations for Anti-inflammatory Treatments in Alzheimer's Disease: A Comprehensive Review of the Literature

被引：51

作者：

Ali, Muhammad Mohsin ^{[1
]}

Ghouri, Raza G. ^{[1
]}

Ans, Armghan H. ^{[2
]}

Akbar, Arshia ^{[3
]}

Toheed, Ahmed ^{[1
]}

机构：

[1] King Edward Med Univ, Mayo Hosp, Internal Med, Lahore, Pakistan

[2] Univ Penn, Cardiol, Philadelphia, PA 19104 USA

[3] Rawalpindi Med Coll, Internal Med, Rawalpindi, Pakistan

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2019年 / 11卷 / 05期

关键词：

dementia; alzheimer disease; anti-inflammatory agents; non-steroidal anti-inflammatory drugs (nsaid); cognitive impairment; degenerative disease; neuroinflammation; disease prevention; LEWY BODY; DRUGS; PREVENTION; TRIAL; RISK; METAANALYSIS; PROGRESSION; DEMENTIA; PLACEBO; NSAIDS;

D O I：

10.7759/cureus.4620

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, affecting individuals older than 60 years. It is a complex degenerative brain disease characterized by progressive cognitive impairment. AD constitutes a major global health concern. A central role for inflammation has been implicated in the pathogenesis of AD. Despite the understanding of multiple molecular pathways in the pathophysiology of AD, novel treatment agents with a possible role in modifying the disease activity are still lacking. Our article provides a comprehensive review of various observational studies and randomized trials encompassing the use of anti-inflammatory agents in the management of AD patients and utilizes the conclusions derived there from to give recommendations in this regard.

引用

页数：6

共 24 条

[1] Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial [J].

Aisen, PS ;

Schafer, KA ;

Grundman, M ;

Pfeiffer, E ;

Sano, M ;

Davis, KL ;

Farlow, MR ;

Jin, S ;

Thomas, RG ;

Thal, LJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2819-2826

[2] 2018 Alzheimer's disease facts and figures [J].

不详 .

ALZHEIMERS & DEMENTIA, 2018, 14 (03) :367-425

[3] NSAIDs as potential treatment option for preventing amyloid toxicity in Alzheimer's disease: an investigation by docking, molecular dynamics, and DFT studies [J].

Azam, Faizul ;

Alabdullah, Nada Hussin ;

Ehmedat, Hadeel Mohammed ;

Abulifa, Abdullah Ramadan ;

Taban, Ismail ;

Upadhyayula, Sreedevi .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2018, 36 (08) :2099-2117

[4] Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the state of Florida Brain Bank [J].

Barker, WW ;

Luis, CA ;

Kashuba, A ;

Luis, M ;

Harwood, DG ;

Loewenstein, D ;

Waters, C ;

Jimison, P ;

Shepherd, E ;

Sevush, S ;

Graff-Radford, N ;

Newland, D ;

Todd, M ;

Miller, B ;

Gold, M ;

Heilman, K ;

Doty, L ;

Goodman, I ;

Robinson, B ;

Pearl, G ;

Dickson, D ;

Duara, R .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2002, 16 (04) :203-212

[5] Results of a follow-up study to the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) The Alzheimer's Disease Anti-inflammatory Prevention Trial Research Group [J].

Breitner, John ;

Baker, Laura ;

Drye, Lea ;

Evans, Denis ;

Lyketsos, Constantine ;

Ryan, Laurie ;

Zandi, Peter ;

Baker, Laura ;

Breitner, John ;

Saucedo, Hector Hernandez ;

Anau, Jane ;

Cholerton, Brenna ;

Kramer, Kirise ;

Zandi, Peter ;

Drye, Lea ;

Casper, Anne Shanklin ;

Meinert, Curtis ;

Martin, Barbara ;

Jenkins, Gabrielle ;

McCaffrey, Lee ;

Meinert, Jill ;

Vaidya, Vijay ;

Ahuja, Alka ;

May, Pat ;

Ryan, Laurie ;

Lyketsos, Constantine G. ;

Steinberg, Martin ;

Brandt, Jason ;

Pedroso, Julia J. ;

Bergey, Alyssa ;

Gogel, Carol ;

Smith, Lynn ;

Kraus, Jennifer ;

Stern, Robert A. ;

Green, Robert C. ;

Gavett, Brandon ;

Mwicigi, Jane ;

Baldwin, Lorraine ;

McGowan, Theresa ;

Johnson, Patricia ;

Qiu, Wendy ;

Frederick, Jamie ;

Raghavan, Sumati ;

Rossi, Carol ;

Mandell, Alan ;

Dinizo, Daniella ;

Roth, Mary Tara ;

Porsteinsson, Anton ;

Ismail, M. Saleem ;

Weber, Miriam .

ALZHEIMERS & DEMENTIA, 2013, 9 (06) :714-723

[6] Extended results of the Alzheimer's disease anti-inflammatory prevention trial [J].

Breitner, John C. ;

Baker, Laura D. ;

Montine, Thomas J. ;

Meinert, Curtis L. ;

Lyketsos, Constantine G. ;

Ashe, Karen H. ;

Brandt, Jason ;

Craft, Suzanne ;

Evans, Denis E. ;

Green, Robert C. ;

Ismail, M. Saleem ;

Martin, Barbara K. ;

Mullan, Michael J. ;

Sabbagh, Marwan ;

Tariot, Pierre N. .

ALZHEIMERS & DEMENTIA, 2011, 7 (04) :402-411

[7] Targeting neuroinflammation in Alzheimer's disease: evidence for NSAIDs and novel therapeutics [J].

Deardorff, William James ;

Grossberg, George T. .

EXPERT REVIEW OF NEUROTHERAPEUTICS, 2017, 17 (01) :17-32

[8] Role of Traditional Nonsteroidal Anti-inflammatory Drugs in Alzheimer's Disease: A Meta-analysis of Randomized Clinical Trials [J].

Gupta, Prem Prakash ;

Pandey, Rishabh Dev ;

Jha, Diwakar ;

Shrivastav, Vikesh ;

Kumar, Sandeep .

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2015, 30 (02) :178-182

[9] Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment? [J].

Imbimbo, Bruno P. ;

Solfrizzi, Vincenzo ;

Panza, Francesco .

FRONTIERS IN AGING NEUROSCIENCE, 2010, 2

[10] Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease [J].

in 't Veld, BA ;

Ruitenberg, A ;

Hofman, A ;

Launer, LJ ;

van Duijn, CM ;

Stijnen, T ;

Breteler, MMB ;

Stricker, BHC .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (21) :1515-1521

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