Embryonic Stem Cells in Development and Regenerative Medicine

被引：23

作者：

Dogan, Aysegul ^{[1
]}

机构：

[1] NCI, CDBL, NIH, Frederick, MD 21701 USA

来源：

CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 1: STEM CELLS IN REGENERATIVE MEDICINE: ADVANCES AND CHALLENGES | 2018年 / 1079卷

关键词：

Embryonic stem cells; Development; Differentiation; Regenerative medicine; Tissue engineering; SPINAL-CORD-INJURY; CHONDROGENIC DIFFERENTIATION; IN-VITRO; MOUSE; TRANSPLANTATION; CARDIOMYOCYTES; CARTILAGE; PROGENITORS; GENERATION; LINES;

D O I：

10.1007/5584_2018_175

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

After progressive improvement in embryonic stem (ES) cell field, several studies have been conducted to explore the usage of ES cells in regenerative medicine. Unlimited self renewal and pluripoteny properties, combined with encouraging preclinical trials, remark that ES cell technology might be promising for clinical practice. ES cells, which can form three germ layers in vitro, are potential candidates to study development at the cellular and molecular level. Understanding the cell fate decision and differentiation processes during development might enable generating functional progenitor cells for tissue restoration. Progression in gene modifications and tissue engineering technology has facilitated the derivation of desired cells for therapy. Success in differentiation protocols and identification the regulatory pathways simplify the research for clinical applications. Although there are established protocols for cell differentiation in vitro and promising preclinical studies in vivo, many challenges need to be adressed before clinical translation. In this review, ES cells are discussed as a model of development in vitro and as a potential candidate for regenerative medicine. This review also dissusses current challenges for ES cell based therapy.

引用

页码：1 / 15

页数：15

共 94 条

[1] Influence of oriented nanofibrous PCL scaffolds on quantitative gene expression during neural differentiation of mouse embryonic stem cells [J].

Abbasi, Naghmeh ;

Hashemi, Seyed Mahmoud ;

Salehi, Mohammad ;

Jahani, Hoda ;

Mowla, Seyed Javad ;

Soleimani, Masoud ;

Hosseinkhani, Hossein .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2016, 104 (01) :155-164

[2] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [J].

Adewumi, Oluseun ;

Aflatoonian, Behrouz ;

Ahrlund-Richter, Lars ;

Amit, Michal ;

Andrews, Peter W. ;

Beighton, Gemma ;

Bello, Paul A. ;

Benvenisty, Nissim ;

Berry, Lorraine S. ;

Bevan, Simon ;

Blum, Barak ;

Brooking, Justin ;

Chen, Kevin G. ;

Choo, Andre B. H. ;

Churchill, Gary A. ;

Corbel, Marie ;

Damjanov, Ivan ;

Draper, Jon S. ;

Dvorak, Petr ;

Emanuelsson, Katarina ;

Fleck, Roland A. ;

Ford, Angela ;

Gertow, Karin ;

Gertsenstein, Marina ;

Gokhale, Paul J. ;

Hamilton, Rebecca S. ;

Hampl, Ales ;

Healy, Lyn E. ;

Hovatta, Outi ;

Hyllner, Johan ;

Imreh, Marta P. ;

Itskovitz-Eldor, Joseph ;

Jackson, Jamie ;

Johnson, Jacqueline L. ;

Jones, Mark ;

Kee, Kehkooi ;

King, Benjamin L. ;

Knowles, Barbara B. ;

Lako, Majlinda ;

Lebrin, Franck ;

Mallon, Barbara S. ;

Manning, Daisy ;

Mayshar, Yoav ;

Mckay, Ronald D. G. ;

Michalska, Anna E. ;

Mikkola, Milla ;

Mileikovsky, Masha ;

Minger, Stephen L. ;

Moore, Harry D. ;

Mummery, Christine L. .

NATURE BIOTECHNOLOGY, 2007, 25 (07) :803-816

[3] Transgenic human embryonic stem cells overexpressing FGF2 stimulate neuroprotection following spinal cord ventral root avulsion [J].

Araujo, Marta Rocha ;

Kyrylenko, Sergiy ;

Spejo, Aline Barroso ;

Castro, Mateus Vidigal ;

Ferreira Junior, Rui Seabra ;

Barraviera, Benedito ;

Rodrigues Oliveira, Alexandre Leite .

EXPERIMENTAL NEUROLOGY, 2017, 294 :45-57

[4] Insulin production by human embryonic stem cells [J].

Assady, S ;

Maor, G ;

Amit, M ;

Itskovitz-Eldor, J ;

Skorecki, KL ;

Tzukerman, M .

DIABETES, 2001, 50 (08) :1691-1697

[5] Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells [J].

Ben-David, Uri ;

Nudel, Neta ;

Benvenisty, Nissim .

NATURE COMMUNICATIONS, 2013, 4

[6] Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats [J].

Ben-Hur, T ;

Idelson, M ;

Khaner, H ;

Pera, M ;

Reinhartz, E ;

Itzik, A ;

Reubinoff, BE .

STEM CELLS, 2004, 22 (07) :1246-1255

[7] Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing β-cell-like cells [J].

Brolén, GKC ;

Heins, N ;

Edsbagge, J ;

Semb, H .

DIABETES, 2005, 54 (10) :2867-2874

[8] Properties of four human embryonic stem cell lines maintained in a feeder-free culture system [J].

Carpenter, MK ;

Rosler, ES ;

Fisk, GJ ;

Brandenberger, R ;

Ares, X ;

Miura, T ;

Lucero, M ;

Rao, MS .

DEVELOPMENTAL DYNAMICS, 2004, 229 (02) :243-258

[9] Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardiol performance in infrcted rat hearts [J].

Caspi, Oren ;

Huber, Irit ;

Kehat, Izhak ;

Habib, Manhal ;

Arbel, Gil ;

Gepstein, Amira ;

Yankelson, Lior ;

Aronson, Doron ;

Beyar, Rafael ;

Gepstein, Lior .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (19) :1884-1893

[10] Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency [J].

Chen, Hongwei ;

Aksoy, Irene ;

Gonnot, Fabrice ;

Osteil, Pierre ;

Aubry, Maxime ;

Hamela, Claire ;

Rognard, Cloe ;

Hochard, Arnaud ;

Voisin, Sophie ;

Fontaine, Emeline ;

Mure, Magali ;

Afanassieff, Marielle ;

Cleroux, Elouan ;

Guibert, Sylvain ;

Chen, Jiaxuan ;

Vallot, Celine ;

Acloque, Herve ;

Genthon, Clemence ;

Donnadieu, Cecile ;

De Vos, John ;

Sanlaville, Damien ;

Guerin, Jean-Francois ;

Weber, Michael ;

Stanton, Lawrence W. ;

Rougeulle, Claire ;

Pain, Bertrand ;

Bourillot, Pierre-Yves ;

Savatier, Pierre .

NATURE COMMUNICATIONS, 2015, 6

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