NIS-Catalyzed Reactions: Amidation of Acetophenones and Oxidative Amination of Propiophenones

被引：152

作者：

Lamani, Manjunath ^{[1
]}

Prabhu, Kandikere Ramaiah ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 46期

关键词：

acetophenones; amination; dehydrogenation; N-iodosuccinimide; oxidation; propiophenones; DOUBLE CARBONYLATION; ALPHA-KETOAMIDES; EFFICIENT SYNTHESIS; ACID-DERIVATIVES; SINGLET OXYGEN; METAL-FREE; INHIBITORS; KETONES; AMIDES; TEMPERATURE;

D O I：

10.1002/chem.201202703

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single-step amination: The N-iodosuccinimide (NIS)-catalyzed amidation of acetophenone derivatives by using tert-butylhydroperoxide (TBHP) as an oxidant is presented. A variety of acetyl derivatives of heterocyclic compounds were easily converted to their corresponding ketoamides under these conditions. A new, NIS-catalyzed amination of propiophenone and its derivatives in the presence of TBHP to furnish the corresponding 2-aminoketone derivatives is the first reported single-step amination of propiophenone derivatives. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：14638 / 14642

页数：5

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