Thyroxine-binding globulin, peripheral deiodinase activity, and thyroid autoantibody status in association of phthalates and phenolic compounds with thyroid hormones in adult population

被引：39

作者：

Choi, Sohyeon ^{[1
]}

Kim, Min Joo ^{[2
]}

Park, Young Joo ^{[2
]}

Kim, Sunmi ^{[3
]}

Choi, Kyungho ^{[3
]}

Cheon, Gi Jeong ^{[4
]}

Cho, Yoon Hee ^{[5
]}

Jeon, Hye Li ^{[6
]}

Yoo, Jiyoung ^{[6
]}

Park, Jeongim ^{[1
]}

机构：

[1] Soonchunhyang Univ, Coll Nat Sci, Asan, South Korea

[2] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[3] Seoul Natl Univ, Sch Publ Hlth, Seoul, South Korea

[4] Seoul Natl Univ, Dept Nucl Med, Coll Med, Seoul, South Korea

[5] Univ Montana, Ctr Environm Hlth Sci, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA

[6] Natl Inst Environm Res, Environm Hlth Res Div, Minist Environm, Incheon, South Korea

来源：

ENVIRONMENT INTERNATIONAL | 2020年 / 140卷

关键词：

Phthalates; Bisphenol A; Parabens; Endocrine Disruptors; Thyroid hormones; BISPHENOL-A; URINARY PHTHALATE; ENVIRONMENTAL CHEMICALS; US ADULTS; EXPOSURE; HEALTH; METABOLITES; TRICLOSAN;

D O I：

10.1016/j.envint.2020.105783

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Exposure to consumer chemicals such as phthalates and phenolic compounds has been associated with thyroid hormone disruption in humans. However, information related to factors that may influence such associations, e.g., transport and activation of the hormones, and autoimmunity status, is limited. In the present study, we employed a subpopulation of adults (n = 1,254) who participated in the Korean National Environmental Health Survey (KoNEHS) 2015-2017, and associated urinary concentrations of major phthalate metabolites, bisphenol A (BPA), and parabens, with thyroid hormone-related measures, including free and total T3 and T4, TSH, thyroxine-binding globulin (TBG), calculated peripheral deiodinase (DIO) activity, and thyroid autoantibodies of thyroperoxidase (TPO) and thyroglobulin (Tg). Phthalate metabolites were negatively associated with total T4 and free T3, and positively associated with total T3. These observations could be explained by TBG levels and calculated peripheral DIO activity that were positively associated with phthalates exposure. In contrast, BPA was positively associated with total T4 and negatively associated with total T3, without any changes in TBG concentration. Serum TPO and Tg antibodies were not associated with urinary phthalate metabolites and BPA. However, thyroid autoantibody status appeared to modulate the association of some phthalates with thyroid hormones. For parabens, little to negligible association was observed. The results of our observation show potential underlying mechanisms of phthalates-induced thyroid hormone disruption, and suggests the importance of consideration of thyroid autoimmunity status in association studies for thyroid disrupting chemicals.

引用

页数：10

共 34 条

[11]

Gore AC, 2015, ENDOCR REV, V36, pE1, DOI 10.1210/er.2015-1010

[12] Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013 [J].