Effects of Papaver rhoeas extract on the tolerance development to analgesic effects of morphine in mice

被引：0

作者：

Shams, Jamal ^{[1
,2
]}

Sahraei, Hedayat ^{[3
,4
]}

Faghih-Monzavi, Zohreh ^{[5
]}

Salimi, Seyed Hossein ^{[6
]}

Fatemi, Seyedeh Maedeh ^{[4
]}

Pourmatabbed, Ali ^{[7
]}

Ghoshooni, Hassan ^{[3
,8
]}

Kamalinejad, Mohammad ^{[9
]}

机构：

[1] Shaheed Behesti Univ Med Sci, Neurosci Res Ctr, Tehran, Iran

[2] Shaheed Behesti Univ Med Sci, Sch Med, Dept Psychiat, Tehran, Iran

[3] Baqiyatallah AS Univ Med Sci, Sch Med, Dept Physiol & Biophys, Tehran, Iran

[4] Baqiyatallah AS Univ Med Sci, ANRC, Div Neurobiol, Tehran, Iran

[5] Islamic Azad Univ, N Tehran Branch, Sch Sci, Dept Biol, Tehran, Iran

[6] Baqiyatallah AS Univ Med Sci, Sch Med, Dept Psychol, Tehran, Iran

[7] Kermanshah Univ Med Sci, Sch Med, Dept Physiol, Kermanshah, Iran

[8] Baqiyatallah AS Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran

[9] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran

来源：

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2008年 / 7卷 / 02期

关键词：

Papaver rhoeas; morphine; analgesia; tolerance; mice;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. However, intrapretoneal administration of the hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg) had not an effects on analgesia. Reduction of analgesic in mice pretreated with morphine (50 mg/kg, twice daily; for 3 days), alone, indicated that tolerance has been developed. Hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of three daily doses of morphine, attenuated the morphine tolerance dose-independently, indicating that administration of the extract reduces morphine tolerance in mice.

引用

页码：141 / 147

页数：7

共 26 条

[1]

[Anonymous], 2001, Goodman Gilman's

[2] MORPHINE-TOLERANCE AND PHYSICAL-DEPENDENCE - INFLUENCE OF CHOLINERGIC AGONISTS AND ANTAGONISTS [J].

BHARGAVA, HN ;

WAY, EL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1976, 36 (01) :79-88

[3] Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat [J].

Cook, CD ;

Carroll, FI ;

Beardsley, PM .

PSYCHOPHARMACOLOGY, 2001, 159 (01) :58-63

[4] Opiate tolerance and dependence: Receptors, G-proteins, and antiopiates [J].

Harrison, LM ;

Kastin, AJ ;

Zadina, JE .

PEPTIDES, 1998, 19 (09) :1603-1630

[5]

KALAV Y N, 1989, Planta Medica, V55, P488

[6] Potentiation of opioid analgesia in dopamine2 receptor knock-out mice:: Evidence for a tonically active anti-opioid system [J].

King, MA ;

Bradshaw, S ;

Chang, AH ;

Pintar, JE ;

Pasternak, GW .

JOURNAL OF NEUROSCIENCE, 2001, 21 (19) :7788-7792

[7] BLOCKADE OF TOLERANCE TO MORPHINE BUT NOT TO KAPPA-OPIOIDS BY A NITRIC-OXIDE SYNTHASE INHIBITOR [J].

KOLESNIKOV, YA ;

PICK, CG ;

CISZEWSKA, G ;

PASTERNAK, GW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5162-5166

[8] Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence [J].

Law, PY ;

Loh, HH ;

Wei, LN .

NEUROPHARMACOLOGY, 2004, 47 :300-311

[9] THIN-LAYER CHROMATOGRAPHY AND DENSITOMETRY OF ANTHOCYANINS IN THE PETALS OF RED POPPY DURING DEVELOPMENT OF THE FLOWERS [J].

MATYSIK, G ;

BENESZ, M .

CHROMATOGRAPHIA, 1991, 32 (1-2) :19-22

[10] The effects of LY293558, an AMPA receptor antagonist, on acute and chronic morphine dependence [J].

McLemore, GL ;

Kest, B ;

Inturrisi, CE .

BRAIN RESEARCH, 1997, 778 (01) :120-126

← 1 2 3 →