Panel of Prototypical Recombinant Infectious Molecular Clones Resistant to Nevirapine, Efavirenz, Etravirine, and Rilpivirine

被引：21

作者：

Balamane, Maya ^{[1
]}

Varghese, Vici ^{[1
]}

Melikian, George L. ^{[1
]}

Fessel, W. Jeffrey ^{[2
]}

Katzenstein, David A. ^{[1
]}

Shafer, Robert W. ^{[1
]}

机构：

[1] Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA

[2] Kaiser Permanente Med Care Program No Calif, San Francisco, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 08期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE INHIBITORS; DRUG-RESISTANCE; WILD-TYPE; HIV-1; PATTERNS; FITNESS;

D O I：

10.1128/AAC.00648-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We created a panel of 10 representative multi-nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant recombinant infectious molecular HIV-1 clones to assist researchers studying NNRTI resistance or developing novel NNRTIs. The cloned viruses contain most of the major NNRTI resistance mutations and most of the significantly associated mutation pairs that we identified in two network analyses. Each virus in the panel has intermediate- or high-level resistance to all or three of the four most commonly used NNRTIs.

引用

页码：4522 / 4524

页数：3

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