Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient

被引:6
|
作者
Thien, S. Y. [1 ]
Chung, S. J. [1 ]
Tan, A. L. [2 ]
Hwang, W. Y. K. [3 ]
Tan, B. H. [1 ]
Tan, T. T. [1 ]
机构
[1] Singapore Gen Hosp, Dept Infect Dis, Level 3,20 Coll Rd, Singapore 169865, Singapore
[2] Singapore Gen Hosp, Dept Pathol, Singapore, Singapore
[3] Singapore Gen Hosp, Dept Hematol, Singapore, Singapore
关键词
trichosporonosis; Trichosporon asahii; hematopoietic stem cell transplant; aplastic anemia; central nervous system infection; hydrocephalus; ACUTE MYELOID-LEUKEMIA; BREAKTHROUGH TRICHOSPORONOSIS; HEMATOLOGIC MALIGNANCIES; FUNGAL-INFECTIONS; ANTIFUNGAL AGENTS; ASAHII INFECTION; VORICONAZOLE; PATIENT; POSACONAZOLE; FUNGEMIA;
D O I
10.1111/tid.12577
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Trichosporon is an ubiquitous yeast that has emerged as an opportunistic pathogen in the immunocompromised host. We describe a case of invasive trichosporonosis in an allogeneic hematopoietic stem cell transplant (allo-HSCT) recipient while on caspofungin antifungal prophylaxis. She developed disseminated trichosporonosis in the pre-engraftment period and was successfully treated with voriconazole. She later developed 2 further episodes of invasive trichosporonosis involving the central nervous system. This case highlights the challenges of managing trichosporonosis in allo-HSCT recipients and suggests the need for lifelong therapy in some patients.
引用
收藏
页码:768 / 772
页数:5
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