Towards retinal ganglion cell regeneration

被引：1

作者：

Gao, Huasong ^{[1
]}

Zhang, Helen L. ^{[2
]}

Shou, Jiajun ^{[1
]}

Chen, Luping ^{[1
]}

Shen, Yiwen ^{[1
]}

Tang, Qisheng ^{[1
]}

Huang, Jiongwei ^{[1
]}

Zhu, Jianhong ^{[1
]}

机构：

[1] Fudan Univ, Dept Neurosurg, Natl Key Lab Med Neurobiol, Shangai Med Coll,Huashan Hosp,Inst Brain Sci, Shanghai 200433, Peoples R China

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA

来源：

REGENERATIVE MEDICINE | 2012年 / 7卷 / 06期

关键词：

cell replacement; cell transplantation; glaucoma; optic nerve injury; regeneration; retinal ganglion cell; MYELIN-ASSOCIATED GLYCOPROTEIN; OPTIC-NERVE CRUSH; OLFACTORY ENSHEATHING CELLS; EMBRYONIC STEM-CELLS; OPEN-ANGLE GLAUCOMA; LONG-TERM SURVIVAL; AXONAL REGENERATION; ADULT-RAT; NEURITE OUTGROWTH; PROGENITOR CELLS;

D O I：

10.2217/RME.12.97

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Traumatic optic nerve injury and glaucoma are among the leading causes of incurable vision loss across the world. What is worse, neither pharmacological nor surgical interventions are significantly effective in reversing or halting the progression of vision loss. Advances in cell biology offer some hope for the victims of optic nerve damage and subsequent partial or complete visual loss. Retinal ganglion cells (RGCs) travel through the optic nerve and carry all visual signals to the brain. After injury, RGC axons usually fail to regrow and die, leading to irreversible loss of vision. Various kinds of cells and factors possess the ability to support the process of axon regeneration for RGCs. This article summarizes the latest advances in RGC regeneration.

引用

页码：865 / 875

页数：11

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