Synthesis of the furanosteroidal antibiotic viridin

被引：106
作者：
Anderson, EA
Alexanian, EJ
Sorensen, EJ
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 15期
关键词：
cyclotrimerization; dihydroxylation; electrocyclic reactions; inhibitors; natural products;
D O I：
10.1002/anie.200353129
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A rhodium-catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy-directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.
引用
收藏
页码：1998 / 2001
页数：4
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