Thiourea-catalyzed direct reductive amination of aldehydes

被引：48

作者：

Menche, D ^{[1
]}

Arikan, F ^{[1
]}

机构：

[1] Gesell Biotechnol Forsch mbH, Med Chem, D-38124 Braunschweig, Germany

来源：

SYNLETT | 2006年 / 06期

关键词：

amines; reductions; organocatalysis; hydrogen bonds; aminations;

D O I：

10.1055/s-2006-939052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A hydrogen-bond-catalyzed direct reductive amination of aldehydes is reported. The acid- and metal-free process uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation and allows for the high-yielding synthesis of diverse amines.

引用

页码：841 / 844

页数：4

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