3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora and their inhibitory effects on nitric oxide production

被引：33

作者：

Zhang, Lei ^{[1
]}

Dong, Lin ^{[2
]}

Huang, Jian ^{[1
]}

Liu, Mingsheng ^{[3
]}

Li, Guoyu ^{[4
]}

Zhang, Cui ^{[1
]}

Zhang, Ke ^{[4
]}

Wang, Jinhui ^{[1
,4
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China

[2] Hainan Med Coll, Hainan Prov Key Lab R&D Trop Med Plants, Haikou 571199, Peoples R China

[3] Acad South Med & Li Med Hainan Prov, Haikou 571199, Peoples R China

[4] Shihezi Univ, Sch Pharm, Shihezi 832023, Peoples R China

来源：

FITOTERAPIA | 2013年 / 89卷

关键词：

3; 4-seco-Labdane diterpenoids; Callicarpa nudiflora; Nitric oxide; RAW; 264.7; AJUGA-NIPPONENSIS; GALBANIC ACID; SESQUITERPENE; ETHERS;

D O I：

10.1016/j.fitote.2013.05.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a part of our ongoing search for bioactive compounds from the leaves of Callicarpa nudiflora that inhibit nitric oxide (NO) production, the 90% EtOH fraction eluted by macroporous resin adsorption was found to show significant inhibitory activity against the production of NO in RAW 264.7 stimulated by lipopolysaccharide (U'S). Bioactivity-guided isolation of the fraction yielded three new bioactive diterpenoids, named ent-3, 4-seco-14-carbonyl-15, 16-epoxy-4(18), 8(17), 13(14)-labdatrien-3-oic acid (1), syn-3, 4-seco-12R-hydroxy-15, 16-epoxy-4(18), 8(17), 13(16), 14(15)-labdatetraen-3-oic acid (2) and syn-3, 4-seco-12S-hydroxy-15, 16-epoxy-4(18), 8(17), 13(16), 14(15)-labdatetraen-3-oic acid (3). Their structures and configurations were elucidated by comprehensive spectroscopic analysis. All the three compounds exhibited potent inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：218 / 223

页数：6

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