The increased antibody response to Epstein-Barr virus in multiple sclerosis is restricted to selected virus proteins

被引：16
作者：
Dooley, Matthew M. [1 ]
de Gannes, Samantha L. [1 ]
Fu, Kristi A. [1 ]
Lindsey, J. William [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Dept Neurol, 6431 Fannin St, Houston, TX 77030 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 299卷
关键词：
Multiple sclerosis; Epstein-Barr virus; Antibody response; EBNA-1; BFRF3; BRRF2; IMMUNE-RESPONSE; INFECTION; RISK;
D O I：
10.1016/j.jneuroim.2016.08.016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, and the antibody response to EBV is reported to be increased in MS. EBV contains multiple antigens, and only a few have been investigated. Our hypothesis is that MS patients will have an increased antibody response to only selected EBV antigens. We used immunoprecipitation and quantitative mass spectrometry to identify candidate EBV antigens. We then measured the antibody response to 10 individual EBV proteins with quantitative ELISA. We found that the antibody response was increased in MS to three of the EBV proteins, but not to the other seven. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：147 / 151
页数：5
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