Nutrient sensing, signal transduction and immune responses

被引：48

作者：

Walls, Jessica ^{[1
]}

Sinclair, Linda ^{[3
]}

Finlay, David ^{[1
,2
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin 2, Ireland

[2] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Trinity Biomed Sci Inst, Dublin, Ireland

[3] Univ Dundee, Div Cell Signalling & Immunol, Sch Life Sci, Dundee DD1 4HN, Scotland

来源：

SEMINARS IN IMMUNOLOGY | 2016年 / 28卷 / 05期

基金：

英国惠康基金; 爱尔兰科学基金会;

关键词：

Immunometabolism; Nutrient sensing; Glucose; Glutamine; Amino acids; SCFA; LCFA; Cholesterol; Oxysterols; Srebp; mTORC1; c-Myc; GCN2; Slc7a5; CD36; LXR; Glycolysis; OxPhos; Lymphocyte; Macrophage; LIVER X RECEPTORS; PROTEIN-COUPLED RECEPTOR; ESSENTIAL AMINO-ACIDS; T-CELL-ACTIVATION; CHAIN FATTY-ACIDS; O-GLCNACYLATION; FUNCTIONAL-CHARACTERIZATION; METABOLITE BUTYRATE; STEROL-METABOLISM; GLUTAMINE UPTAKE;

D O I：

10.1016/j.smim.2016.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immune response. Cells of the immune system frequently operate in complex nutrient restricted microenvironments such as tumour or inflammatory sites. The concentrations of key nutrients such as glucose and certain amino acids, can be low at these sites, and this can have an impact upon immune cell function. Nutrient sufficiency is important to supply the metabolic and biosynthetic pathways of immune cells. In addition nutrients can also act as important cues that influence immunological signalling pathways to affect the function of immune cells. This review will describe the various nutrient sensing signalling pathways and discuss the evidence that nutrients are critical signals that shape immune responses. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：396 / 407

页数：12

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