Association of Epicardial Fat With Cardiovascular Risk Factors and Incident Myocardial Infarction in the General Population

被引：423

作者：

Mahabadi, Amir A. ^{[1
]}

Berg, Marie H. ^{[2
]}

Lehmann, Nils ^{[2
]}

Kaelsch, Hagen ^{[1
]}

Bauer, Marcus ^{[1
]}

Kara, Kaffer ^{[1
]}

Dragano, Nico ^{[3
]}

Moebus, Susanne ^{[2
]}

Joeckel, Karl-Heinz ^{[2
]}

Erbel, Raimund ^{[1
]}

Moehlenkamp, Stefan ^{[1
,4
]}

机构：

[1] Univ Duisburg Essen, Dept Cardiol, West German Heart Ctr, D-45147 Essen, Germany

[2] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, D-45147 Essen, Germany

[3] Univ Clin Dusseldorf, Inst Med Sociol, Ctr Hlth & Soc, Dusseldorf, Germany

[4] Krankenhaus Bethanien, Dept Cardiol, Moers, Germany

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2013年 / 61卷 / 13期

关键词：

epicardial fat; epidemiology; Heinz Nixdorf Recall study; myocardial infarction; risk prediction; HEINZ NIXDORF RECALL; CORONARY-ARTERY-DISEASE; VISCERAL ABDOMINAL FAT; ADIPOSE-TISSUE; PERICARDIAL FAT; COMPUTED-TOMOGRAPHY; ATHEROSCLEROSIS; BURDEN; QUANTIFICATION; CALCIFICATION;

D O I：

10.1016/j.jacc.2012.11.062

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives This study sought to determine whether epicardial fat volume predicts coronary events in the general population. Background Epicardial adipose tissue (EAT) is suggested to promote plaque development in the coronary artery tree. Methods We quantified EAT volume in participants from the prospective population-based Heinz Nixdorf Recall cohort study free of cardiovascular disease. Incident coronary events were assessed during a follow-up period of 8.0 +/- 1.5 years. Multivariable association of EAT with cardiovascular risk factors, coronary artery calcification (CAC), and coronary events was assessed using regression analysis. Results From the overall 4,093 participants (age 59.4 years, 47% male), 130 subjects developed a fatal or nonfatal coronary event. Incidence of coronary events increased by quartile of EAT (0.9% vs. 4.7% for 1st and 4th quartile, respectively, p < 0.001). Doubling of EAT was associated with a 1.5-fold risk of coronary events when adjusting for cardiovascular risk factors (hazard ratio [HR] [95% confidence interval (CI)]: 1.54 [1.09 to 2.19]), which remained unaltered after further adjustment for CAC score (HR [95% CI]: 1.50 [1.07 to 2.11]). For discrimination of subjects with events from those without, we observed a trend for improvement of Harrell's C and explained variance by EAT over traditional cardiovascular risk factors, which, however, did not reach statistical significance (0.720 to 0.730 for risk factors alone and with EAT added, respectively, p = 0.10, R-2 = 2.73% to R-2 = 2.92%, time-dependent integrated discrimination improvement = 0.196%). Conclusions Epicardial fat is associated with fatal and nonfatal coronary events in the general population independent of traditional cardiovascular risk factors and complements information from cardiac computed tomography above the CAC score. (J Am Coll Cardiol 2013;61:1388-95) (C) 2013 by the American College of Cardiology Foundation

引用

页码：1388 / 1395

页数：8

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