Cloning humans? Biological, ethical, and social considerations

被引:23
作者
Ayala, Francisco J. [1 ]
机构
[1] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA
关键词
human origins; natural selection; cultural evolution; genetic therapy; therapeutic cloning; LEBERS CONGENITAL AMAUROSIS; GENE-THERAPY; DISEASE; TRIAL;
D O I
10.1073/pnas.1501798112
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
There are, in mankind, two kinds of heredity: biological and cultural. Cultural inheritance makes possible for humans what no other organism can accomplish: the cumulative transmission of experience from generation to generation. In turn, cultural inheritance leads to cultural evolution, the prevailing mode of human adaptation. For the last few millennia, humans have been adapting the environments to their genes more often than their genes to the environments. Nevertheless, natural selection persists in modern humans, both as differential mortality and as differential fertility, although its intensity may decrease in the future. More than 2,000 human diseases and abnormalities have a genetic causation. Health care and the increasing feasibility of genetic therapy will, although slowly, augment the future incidence of hereditary ailments. Germline gene therapy could halt this increase, but at present, it is not technically feasible. The proposal to enhance the human genetic endowment by genetic cloning of eminent individuals is not warranted. Genomes can be cloned; individuals cannot. In the future, therapeutic cloning will bring enhanced possibilities for organ transplantation, nerve cells and tissue healing, and other health benefits.
引用
收藏
页码:8879 / 8886
页数:8
相关论文
共 43 条
[1]   GENE-THERAPY - ITALIANS 1ST TO USE STEM-CELLS [J].
ABBOTT, A .
NATURE, 1992, 356 (6369) :465-465
[2]  
[Anonymous], 1988, Culture and the evolutionary process
[3]  
[Anonymous], ORIGIN EVOLUTION CUL
[4]  
[Anonymous], 2005, NOT GENES ALONE
[5]  
[Anonymous], 2013, Scientific American Blog Network
[6]  
Arias Elizabeth, 2010, Natl Vital Stat Rep, V58, P1
[7]  
Ayala F.J., 1984, MODERN GENETICS, Vsecond
[8]  
AYALA FJ, 1986, AM ZOOL, V26, P895
[9]  
Ayala FJ., 1982, Population and Evolutionary Genetics: A Primer
[10]  
Ayala FranciscoJ., 2007, Darwin's Gift to Science and Religion, DOI DOI 10.1073/pnas.0914616107