Detection and risk assessments of multi-pesticides in 1771 cultivated herbal medicines by LC/MS-MS and GC/MS-MS

被引：58

作者：

Luo, Lu ^{[1
]}

Dong, Linlin ^{[1
]}

Huang, Qin ^{[1
]}

Ma, Shuangcheng ^{[2
]}

Fantke, Peter ^{[3
]}

Li, Jianhui ^{[4
]}

Jiang, Jingwen ^{[5
]}

Fitzgerald, Martin ^{[6
]}

Yang, Jane ^{[4
]}

Jia, Zhengwei ^{[4
]}

Zhang, Jiqing ^{[1
]}

Wang, Haifeng ^{[1
]}

Dai, Yuntao ^{[1
]}

Zhu, Guangwei ^{[1
]}

Xing, Zhihan ^{[7
]}

Liang, Yichuan ^{[1
]}

Li, Mengzhi ^{[1
]}

Wei, Guangfei ^{[1
]}

Song, Jingyuan ^{[8
]}

Wei, Jianhe ^{[8
]}

Peng, Cheng ^{[9
]}

Zhang, Han ^{[10
]}

Zhang, Wei ^{[11
]}

Wang, Shumei ^{[1
]}

Mizuno, Kaito ^{[12
]}

Marco, Alarcon Arauco Gian ^{[13
]}

Wu, Lan ^{[1
]}

Xu, Jiang ^{[1
]}

Xiong, Chao ^{[1
]}

Chen, Shilin ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[2] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China

[3] Tech Univ Denmark, Dept Technol Management & Econ, Quantitat Sustainabil Assessment, Prod Torvet 424, DK-2800 Lyngby, Denmark

[4] Waters Technol Shanghai Ltd, Block 13,1000 Jinhai Rd, Shanghai 201206, Peoples R China

[5] Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu 610041, Peoples R China

[6] Univ Westminster, Dept Life Sci, 115 New Cavendish St, London W1W 6UW, England

[7] Univ Massachusetts, Coll Sci & Math, 100 William T Morrissey Blvd, Boston, MA 02125 USA

[8] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

[9] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Sichuan, Peoples R China

[10] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 301617, Peoples R China

[11] Cent South Univ, Pharmacogenet Res Inst, Inst Clin Pharmacol, Changsha 410008, Hunan, Peoples R China

[12] Suzuka Univ Med Sci, 1001-1 Kishioka, Suzuka 5100293, Japan

[13] Univ Sci & Technol, Intelligence Sci & Technol, Sch Automat & Elect Engn, Beijing 100083, Peoples R China

来源：

CHEMOSPHERE | 2021年 / 262卷

基金：

对外科技合作项目（国际科技项目）;

关键词：

Herbal medicines; Pesticide; Extrinsic contamination; Risk assessment; Public health;

D O I：

10.1016/j.chemosphere.2020.127477

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Focus on the safety of herbal medicines has mainly been directed towards the presence of intrinsic toxicity, as found in the cases of renal and hepatic dysfunction caused by aristolochic acids. However, contamination from extrinsic hazards may impart an even greater reduction in their safety and efficacy. This study reveals that pesticides were present in the majority (88%) of a comprehensive cross-section (n = 1771) of herbal medicine samples. Alarmingly, more than half (59%) contained pesticides over the European Pharmacopoeia (EP) limit, and 43% of them contained 35 varieties of banned, extremely toxic pesticides, eight of which were detected at levels over 500 times higher than the default Maximum Residue Limit (MRL). DDTs, carbofuran, and mevinphos were confirmed as being among the most riskinducing pesticides by three different risk assessment methods, reported to produce carcinogenic, genotoxic, reproductive, and developmental effects, in addition to carrying nephrotoxicity and hepatotoxicity. In light of these findings, and withstanding that extrinsic hazards can be controlled unlike intrinsic toxicity, the authors here strongly recommend the application of herbal medicine qualitycontrol measures and solutions to safeguard against a neglected but certainly potentially serious health risk posed to the majority of the global population that consumes herbal medicines. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：16

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