The Rcs Two-Component System Regulates Expression of Lysozyme Inhibitors and Is Induced by Exposure to Lysozyme

被引：51
作者：
Callewaert, Lien
Vanoirbeek, Kristof G. A.
Lurquin, Ine
Michiels, Chris W.
Aertsen, Abram [1 ]
机构：
[1] Food Microbiol Lab, B-3001 Louvain, Belgium
来源：
JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 06期
关键词：
ESCHERICHIA-COLI K-12; ANTIBIOTIC-RESISTANCE; PHOSPHORELAY; PROTEIN; CONTRIBUTES; STRESS;
D O I：
10.1128/JB.01549-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Escherichia coli Rcs regulon is triggered by antibiotic-mediated peptidoglycan stress and encodes two lysozyme inhibitors, Ivy and MliC. We report activation of this pathway by lysozyme and increased lysozyme sensitivity when Rcs induction is genetically blocked. This lysozyme sensitivity could be alleviated by complementation with Ivy and MliC.
引用
收藏
页码：1979 / 1981
页数：3
相关论文
共 16 条
[1]   Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria [J].
Abergel, Chantal ;
Monchois, Vincent ;
Byrne, Deborah ;
Chenivesse, Sabine ;
Lembo, Frederique ;
Lazzaroni, Jean-Claude ;
Claverie, Jean-Michel .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (15) :6394-6399
[2]   Activation of the Salmonella Typhimurium Mrr protein [J].
Aertsen, Abram ;
Mebrhatu, Mehari Tesfazgi ;
Michiels, Chris W. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (02) :435-439
[3]   A new family of lysozyme inhibitors contributing to lysozyme tolerance in gram-negative bacteria [J].
Callewaert, Lien ;
Aertsen, Abram ;
Deckers, Daphne ;
Vanoirbeek, Kristof G. A. ;
Vanderkelen, Lise ;
Van Herreweghe, Joris M. ;
Masschalck, Barbara ;
Nakimbugwe, Dorothy ;
Robben, Johan ;
Michiels, Chris W. .
PLOS PATHOGENS, 2008, 4 (03)
[4]   GENE DISRUPTION IN ESCHERICHIA-COLI - TCR AND KM(R) CASSETTES WITH THE OPTION OF FLP-CATALYZED EXCISION OF THE ANTIBIOTIC-RESISTANCE DETERMINANT [J].
CHEREPANOV, PP ;
WACKERNAGEL, W .
GENE, 1995, 158 (01) :9-14
[5]   Expression of the tolQRA genes of Escherichia coli K-12 is controlled by the RcsC sensor protein involved in capsule synthesis [J].
Clavel, T ;
Lazzaroni, JC ;
Vianney, A ;
Portalier, R .
MOLECULAR MICROBIOLOGY, 1996, 19 (01) :19-25
[6]   Periplasmic lysozyme inhibitor contributes to lysozyme resistance in Escherichia coli [J].
Deckers, D ;
Masschalck, B ;
Aertsen, A ;
Callewaert, L ;
Van Tiggelen, CGM ;
Atanassova, M ;
Michiels, CW .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (10) :1229-1237
[7]   The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice [J].
Erickson, Kimberly D. ;
Detweiler, Corrella S. .
MOLECULAR MICROBIOLOGY, 2006, 62 (03) :883-894
[8]   The RcsC sensor kinase is required for normal biofilm formation in Escherichia coli K-12 and controls the expression of a regulon in response to growth on a solid surface [J].
Ferrières, L ;
Clarke, DJ .
MOLECULAR MICROBIOLOGY, 2003, 50 (05) :1665-1682
[9]   The role of the Rcs phosphorelay in Enterobacteriaceae [J].
Huang, YH ;
Ferrières, L ;
Clarke, DJ .
RESEARCH IN MICROBIOLOGY, 2006, 157 (03) :206-212
[10]   The Rcs phosphorelay is a cell envelope stress response activated by peptidoglycan stress and contributes to intrinsic antibiotic resistance [J].
Laubacher, Mary E. ;
Ades, Sarah E. .
JOURNAL OF BACTERIOLOGY, 2008, 190 (06) :2065-2074
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