Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

被引:49
作者
Tangeras, Line H. [1 ,2 ,5 ]
Austdal, Marie [3 ,5 ]
Skrastad, Ragnhild B. [4 ,6 ]
Salvesen, Kjell A. [4 ,6 ]
Austgulen, Rigmor [1 ,2 ]
Bathen, Tone F. [3 ]
Iversen, Ann-Charlotte [1 ,2 ]
机构
[1] Norwegian Univ Sci & Technol NTNU, Fac Med, Ctr Mol Inflammat Res, Trondheim, Norway
[2] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Canc Res & Mol Med, Trondheim, Norway
[3] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Circulat & Med Imaging, Trondheim, Norway
[4] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Lab Med Childrens & Womens Hlth, Trondheim, Norway
[5] Univ Trondheim Hosp, St Olavs Hosp, Trondheim, Norway
[6] Univ Trondheim Hosp, St Olavs Hosp, Dept Obstet & Gynecol, Natl Ctr Fetal Med, Trondheim, Norway
关键词
cytokines; first trimester; gestational hypertension; inflammation; preeclampsia; PLACENTAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; INFLAMMATORY CYTOKINES; EARLY-PREGNANCY; LATER LIFE; SERUM; WOMEN; RISK; DISORDERS; PATHOPHYSIOLOGY;
D O I
10.1161/ATVBAHA.115.305817
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate disease-specific early pregnancy serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia for new insight into the underlying pathogeneses and differences between the disorders. Approach and Results The study cohort consisted of 548 pregnant Norwegian women who were either multiparous with previous gestational hypertension or preeclampsia or were nulliparous. Maternal sera at gestational weeks 11(0)-13(6) were assayed for 27 cytokines, C-reactive protein, total cholesterol, high-density lipoprotein, triglyceride, creatinine, calcium, uric acid, and placental growth factor. Compared with normotensive women, women with both hypertensive conditions presented an atherogenic lipid profile at early gestation, but only those later developing gestational hypertension had significantly higher serum levels of interleukin (IL)-5 and IL-12. Comparing the 2 hypertensive pregnancy disorders, women subsequently developing gestational hypertension had higher serum levels of IL-1, IL-5, IL-7, IL-8, IL-13, basic fibroblast growth factor, and vascular endothelial growth factor than the women subsequently developing preeclampsia. Conclusions This study identifies early pregnancy differences in serum cytokine profiles for gestational hypertension and preeclampsia.
引用
收藏
页码:2478 / 2485
页数:8
相关论文
共 50 条
[41]   The Association of Familial Hypertension and Risk of Gestational Hypertension and Preeclampsia [J].
Lewandowska, Malgorzata .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (13)
[42]   Patterns of Gestational Hypertension or Preeclampsia Across 2 Pregnancies in Relationship to Chronic Hypertension Development: A Retrospective Cohort Study [J].
Mussa, Joseph ;
Rahme, Elham ;
Dahhou, Mourad ;
Nakhla, Meranda ;
Dasgupta, Kaberi .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2024, 13 (13)
[43]   Impact of gestational hypertension and preeclampsia on fetal gender: A large prospective cohort study in China [J].
Liu, Yingying ;
Li, Nan ;
Li, Zhiwen ;
Zhang, Le ;
Li, Hongtian ;
Zhang, Yali ;
Liu, Jian-meng ;
Ye, Rongwei .
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 2019, 18 :132-136
[44]   Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia [J].
Schuermans, Art ;
Truong, Buu ;
Ardissino, Maddalena ;
Bhukar, Rohan ;
Slob, Eric A. W. ;
Nakao, Tetsushi ;
Dron, Jacqueline S. ;
Small, Aeron M. ;
Cho, So Mi Jemma ;
Yu, Zhi ;
Hornsby, Whitney ;
Antoine, Tajmara ;
Lannery, Kim ;
Postupaka, Darina ;
Gray, Kathryn J. ;
Yan, Qi ;
Butterworth, Adam S. ;
Burgess, Stephen ;
Wood, Malissa J. ;
Scott, Nandita S. ;
Harrington, Colleen M. ;
Sarma, Amy A. ;
Lau, Emily S. ;
Roh, Jason D. ;
Januzzi, James L., Jr. ;
Natarajan, Pradeep ;
Honigberg, Michael C. .
JAMA CARDIOLOGY, 2024, 9 (03) :209-220
[45]   Nitric oxide and peroxynitrite platelet levels in gestational hypertension and preeclampsia [J].
Mazzanti, Laura ;
Raffaelli, Francesca ;
Vignini, Arianna ;
Nanetti, Laura ;
Vitali, Paola ;
Boscarato, Virginia ;
Giannubilo, Stefano R. ;
Tranquilli, Andrea L. .
PLATELETS, 2012, 23 (01) :26-35
[46]   Association of family history with incidence and gestational hypertension outcomes of preeclampsia [J].
Wu, Chia-Tung ;
Kuo, Chang-Fu ;
Lin, Chia-Pin ;
Huang, Yu-Tung ;
Chen, Shao-Wei ;
Wu, Hsien-Ming ;
Chu, Pao-Hsien .
INTERNATIONAL JOURNAL CARDIOLOGY HYPERTENSION, 2021, 9
[47]   Gestational diabetes mellitus, hypertension, and dyslipidemia as the risk factors of preeclampsia [J].
Aziz, Farah ;
Khan, Mohammad Fareed ;
Moiz, Amna .
SCIENTIFIC REPORTS, 2024, 14 (01)
[48]   Higher PAPP-A Values in Pregnant Women Complicated with Preeclampsia Than with Gestational Hypertension [J].
Uriel, Montserrat ;
Infante, Ximena Carolina Romero ;
Franco, Sara Rincon ;
Pinilla, Edgar Antonio Ibanez ;
Rojas, Nydia Alexandra .
REPRODUCTIVE SCIENCES, 2023, 30 (08) :2503-2511
[49]   Gestational hypertension as a subclinical preeclampsia in view of serum levels of angiogenesis-related factors [J].
Hirashima, Chikako ;
Ohkuchi, Akihide ;
Takahashi, Kayo ;
Suzuki, Hirotada ;
Yoshida, Mika ;
Ohmaru, Takako ;
Eguchi, Kazuo ;
Ariga, Haruko ;
Matsubara, Shigeki ;
Suzuki, Mitsuaki .
HYPERTENSION RESEARCH, 2011, 34 (02) :212-217
[50]   Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study [J].
Camara, Louopou Rosalie ;
Arbuckle, Tye Elaine ;
Trottier, Helen ;
Fraser, William Donald .
AMERICAN JOURNAL OF PERINATOLOGY, 2019, 36 (11) :1127-1135