A Novel Synthesis Method of Apogossypolone and its Antitumor Activity

被引：5
作者：
Zhan, Yonghua [1 ]
Jia, Guangfeng [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Educ Minist, Xian 710049, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 02期
关键词：
Gossypol; Apogossypolone; Synthesis; In vitro growth inhibition; Proteins; SMALL-MOLECULE INHIBITORS; BCL-2 FAMILY PROTEINS; CELL-DEATH; APOPTOSIS; DISCOVERY; REGULATORS; REGRESSION; THERAPY; CANCER; POTENT;
D O I：
10.2174/157018009787582589
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A derivative of gossypol, 6,7,6',7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'] binaphthalenyl-1,4,1',4'-tetraone (Apogossypolone, ApoG2), has been synthesized from gossypol acetic acid. Its structure was identified by IR, NMR, MS spectrum and cancer cells in vitro growth inhibition experiments were performed. The results indicate that apogossypolone exerts strong in vitro growth inhibition in human prostate cancer cells, representing a promising cancer therapeutic.
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收藏
页码：129 / 132
页数：4
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