Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model

被引:29
作者
Choi, You Yeon [1 ]
Kim, Mi Hye [1 ]
Hong, Jongki [2 ]
Kim, Sung-Hoon [3 ]
Yang, Woong Mo [1 ]
机构
[1] Kyung Hee Univ, Dept Prescriptionol, Coll Oriental Med, Inst Oriental Med, Seoul 130701, South Korea
[2] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
[3] Kyung Hee Univ, Coll Oriental Med, Canc Prevent Mat Dev Res Ctr, Seoul 130701, South Korea
基金
新加坡国家研究基金会;
关键词
NF-KAPPA-B; ANTIINFLAMMATORY ACTIVITIES; COX-2; EXPRESSION; GENE-EXPRESSION; MAP KINASE; LIVER; INOS; INDUCTION; EXTRACTS;
D O I
10.1155/2013/914563
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Objectives. Ginger rhizomes have a long history of human use, especially with regards to their anti-inflammatory properties. However, the mechanisms by which ginger acts on lipopolysaccharide-(LPS-) induced inflammation have not yet been identified. We investigated the anti-inflammatory effects of dried Zingiber officinalis (DZO) on LPS-induced hepatic injury. Methods. ICR mice were given a DZO water extract (100, 1000 mg/kg) orally for three consecutive days. On the third day, they were administered by LPS intraperitoneally. To investigate the anti-inflammatory effects of DZO, histological, cytokine expression, and protein factor analyses were performed. Results. Oral administration of DZO significantly reduced pathological changes in the liver and proinflammatory cytokines including interferon-(IFN-)gamma and interleukin-(IL-)6 in the serum. In addition, DZO inhibited LPS-induced NF-kappa B activation by preventing degradation of the I kappa B-alpha, as well as the phosphorylation of ERK1/2, SAPK/JNK, and p38 MAPKs. These were associated with a decrease in the expression of inducible nitric oxide synthase (iNOS) and cyclooxyenase-2 (COX-2). Conclusions. Our data provide evidence for the hepatoprotective mechanisms of DZO as an anti-inflammatory effect. Furthermore, use of DZO to treat could provide therapeutic benefits in clinical settings.
引用
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页数:9
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