A map of the distribution of sphingosine 1-phosphate in the spleen

被引：44

作者：

Ramos-Perez, Willy D. ^{[1
]}

Fang, Victoria ^{[1
]}

Escalante-Alcalde, Diana ^{[2
]}

Cammer, Michael ^{[3
]}

Schwab, Susan R. ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10010 USA

[2] Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico

[3] NYU, Microscopy Core, Off Collaborat Sci, Langone Med Ctr, New York, NY USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

SPLENIC MARGINAL ZONE; B-CELL LOCALIZATION; LYMPHOCYTE EGRESS; DENDRITIC CELLS; SPHINGOSINE-1-PHOSPHATE; MICE; LIGAND; TRAFFICKING; PROMOTES; PHOSPHORYLATION;

D O I：

10.1038/ni.3296

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the importance of signaling lipids, many questions remain about their function because few tools are available for charting lipid gradients in vivo. Here we generated a sphingosine 1-phosphate (S1P) reporter mouse and used this mouse to define the distribution of S1P in the spleen. Unexpectedly, the presence of blood did not serve as a predictor of the concentration of signaling-available S1P. Large areas of the red pulp had low concentrations of S1P, while SIP was sensed by cells inside the white pulp near the marginal sinus. The lipid phosphate phosphatase LPP3 maintained low SIP concentrations in the spleen and enabled efficient shuttling of marginal zone B cells. The exquisitely tight regulation of S1P availability might explain how a single lipid can simultaneously orchestrate the movements of many cells of the immune system.

引用

页码：1245 / 1252

页数：8

共 47 条

[21] CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation [J].

Groom, Joanna R. ;

Richmond, Jillian ;

Murooka, Thomas T. ;

Sorensen, Elizabeth W. ;

Sung, Jung Hwan ;

Bankert, Katherine ;

von Andrian, Ulrich H. ;

Moon, James J. ;

Mempel, Thorsten R. ;

Luster, Andrew D. .

IMMUNITY, 2012, 37 (06) :1091-1103

[22] SEPARABLE PORTIONS OF THE CD2 CYTOPLASMIC DOMAIN INVOLVED IN SIGNALING AND LIGAND AVIDITY REGULATION [J].

HAHN, WC ;

BIERER, BE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1831-1836

[23] Testing gene function early in the B cell lineage in mb1-cre mice [J].

Hobeika, E. ;

Thiemann, S. ;

Storch, B. ;

Jumaa, H. ;

Nielsen, P. J. ;

Pelanda, R. ;

Reth, M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (37) :13789-13794

[24] Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity [J].

Kabashima, K ;

Murata, T ;

Tanaka, H ;

Matsuoka, T ;

Sakata, D ;

Yoshida, N ;

Katagiri, K ;

Kinashi, T ;

Tanaka, T ;

Miyasaka, M ;

Nagai, H ;

Ushikubi, F ;

Narumiya, S .

NATURE IMMUNOLOGY, 2003, 4 (07) :694-701

[25] Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism [J].

Kabashima, Kenji ;

Haynes, Nicole M. ;

Xu, Ying ;

Nutt, Stephen L. ;

Allende, Maria L. ;

Proia, Richard L. ;

Cyster, Jason G. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2683-2690

[26] Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs [J].

Kanda, Hidenobu ;

Newton, Rebecca ;

Klein, Russell ;

Morita, Yuka ;

Gunn, Michael D. ;

Rosen, Steven D. .

NATURE IMMUNOLOGY, 2008, 9 (04) :415-423

[27] Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo [J].

Kono, Mari ;

Tucker, Ana E. ;

Tran, Jennifer ;

Bergner, Jennifer B. ;

Turner, Ewa M. ;

Proia, Richard L. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (05) :2076-2086

[28] INDUCIBLE GENE TARGETING IN MICE [J].

KUHN, R ;

SCHWENK, F ;

AGUET, M ;

RAJEWSKY, K .

SCIENCE, 1995, 269 (5229) :1427-1429

[29] Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1 [J].

Liu, CH ;

Thangada, S ;

Lee, MJ ;

Van Brocklyn, JR ;

Spiegel, S ;

Hla, T .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (04) :1179-1190

[30] Expression of LPP3 in Bergmann Glia is Required for Proper Cerebellar Sphingosine-1-Phosphate Metabolism/Signaling and Development [J].

Lopez-Juarez, Alejandro ;

Morales-Lazaro, Sara ;

Sanchez-Sanchez, Roberto ;

Sunkara, Manjula ;

Lomeli, Hilda ;

Velasco, Ivan ;

Morris, Andrew J. ;

Escalante-Alcalde, Diana .

GLIA, 2011, 59 (04) :577-589

← 1 2 3 4 5 →