A map of the distribution of sphingosine 1-phosphate in the spleen

被引：44

作者：

Ramos-Perez, Willy D. ^{[1
]}

Fang, Victoria ^{[1
]}

Escalante-Alcalde, Diana ^{[2
]}

Cammer, Michael ^{[3
]}

Schwab, Susan R. ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10010 USA

[2] Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico

[3] NYU, Microscopy Core, Off Collaborat Sci, Langone Med Ctr, New York, NY USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

SPLENIC MARGINAL ZONE; B-CELL LOCALIZATION; LYMPHOCYTE EGRESS; DENDRITIC CELLS; SPHINGOSINE-1-PHOSPHATE; MICE; LIGAND; TRAFFICKING; PROMOTES; PHOSPHORYLATION;

D O I：

10.1038/ni.3296

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the importance of signaling lipids, many questions remain about their function because few tools are available for charting lipid gradients in vivo. Here we generated a sphingosine 1-phosphate (S1P) reporter mouse and used this mouse to define the distribution of S1P in the spleen. Unexpectedly, the presence of blood did not serve as a predictor of the concentration of signaling-available S1P. Large areas of the red pulp had low concentrations of S1P, while SIP was sensed by cells inside the white pulp near the marginal sinus. The lipid phosphate phosphatase LPP3 maintained low SIP concentrations in the spleen and enabled efficient shuttling of marginal zone B cells. The exquisitely tight regulation of S1P availability might explain how a single lipid can simultaneously orchestrate the movements of many cells of the immune system.

引用

页码：1245 / 1252

页数：8

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