Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

被引：35
作者：
Chini, Eduardo Nunes [1 ,2 ]
Chini, Claudia C. S. [1 ,2 ]
Nin, Veronica [1 ,2 ]
Escande, Carlos [1 ,2 ]
机构：
[1] Mayo Clin Canc Ctr, Kodog Ageing Ctr, Dept Anesthesiol, Lab Signal Transduct, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Rochester, MN 55905 USA
来源：
BIOSCIENCE REPORTS | 2013年 / 33卷
关键词：
aging; cancer; circadian cycle; deleted in breast cancer-1 (DBC1); epigenetics; histone deacetylase (HDAC); metabolism; REV-ERB-ALPHA; SIRT1; DEACETYLASE; NEGATIVE REGULATOR; CIRCADIAN BEHAVIOR; HORMONE RECEPTOR; POOR-PROGNOSIS; DNA-DAMAGE; PROTEIN; EXPRESSION; HISTONE;
D O I：
10.1042/BSR20130062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.
引用
收藏
页码：637 / 643
页数：7
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