The roles of TGFβ in the tumour microenvironment

被引：754
作者：
Pickup, Michael [1 ]
Novitskiy, Sergey [1 ]
Moses, Harold L. [1 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Comprehens Canc Ctr, Nashville, TN 37232 USA
来源：
NATURE REVIEWS CANCER | 2013年 / 13卷 / 11期
基金：
美国国家卫生研究院;
关键词：
GROWTH-FACTOR-BETA; MESENCHYMAL STEM-CELLS; REGULATORY T-CELLS; GENE-EXPRESSION SIGNATURE; MAMMARY EPITHELIAL-CELLS; I KINASE INHIBITOR; BREAST-CANCER; CARCINOMA GROWTH; STROMAL CELLS; DENDRITIC CELLS;
D O I：
10.1038/nrc3603
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-beta, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.
引用
收藏
页码：788 / 799
页数：12
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