The roles of TGFβ in the tumour microenvironment

被引：759

作者：

Pickup, Michael ^{[1
]}

Novitskiy, Sergey ^{[1
]}

Moses, Harold L. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Comprehens Canc Ctr, Nashville, TN 37232 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; MESENCHYMAL STEM-CELLS; REGULATORY T-CELLS; GENE-EXPRESSION SIGNATURE; MAMMARY EPITHELIAL-CELLS; I KINASE INHIBITOR; BREAST-CANCER; CARCINOMA GROWTH; STROMAL CELLS; DENDRITIC CELLS;

D O I：

10.1038/nrc3603

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-beta, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.

引用

页码：788 / 799

页数：12

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