The Impact of Hepatitis A Virus Infection on Hepatitis C Virus Infection: A Competitive Exclusion Hypothesis

被引：6
作者：
Amaku, Marcos [1 ]
Bezerra Coutinho, Francisco Antonio [2 ]
Chaib, Eleazar [2 ]
Massad, Eduardo [2 ,3 ]
机构：
[1] Univ Sao Paulo, Sch Vet Med, Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
[3] London Sch Hyg & Trop Med, London WC1, England
来源：
BULLETIN OF MATHEMATICAL BIOLOGY | 2013年 / 75卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Hepatitis A; Hepatitis C; Competitive exclusion principle; Mathematical models; SUPERINFECTION; DYNAMICS;
D O I：
10.1007/s11538-012-9795-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.
引用
收藏
页码：82 / 93
页数：12
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