Genetic variants in anti-Mullerian hormone-related genes and breast cancer risk: results from the AMBER consortium

被引：1

作者：

Nichols, Hazel B. ^{[1
]}

Graff, Mariaelisa ^{[1
]}

Bensen, Jeannette T. ^{[1
]}

Lunetta, Kathryn L. ^{[2
]}

O'Brien, Katie M. ^{[3
]}

Troester, Melissa A. ^{[1
]}

Williams, Lindsay A. ^{[4
]}

Young, Kristin ^{[1
]}

Hong, Chi-Chen ^{[5
]}

Yao, Song ^{[5
]}

Haiman, Christopher A. ^{[6
]}

Ruiz-Narvaez, Edward A. ^{[7
]}

Ambrosone, Christine B. ^{[5
]}

Palmer, Julie R. ^{[2
]}

Olshan, Andrew F. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Epidmiol, Gillings Sch Global Publ Hlth, 2104F McGavran Greenberg Hall, Chapel Hill, NC 27599 USA

[2] Boston Univ, Slone Epidmiol Ctr, 72 E Concord St, Boston, MA 02118 USA

[3] NIEHS, Epidemiol Branch, Durham, NC USA

[4] Univ Minnesota, Dept Pediat, 2450 Riverside Ave, Minneapolis, MN 55454 USA

[5] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA

[6] Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90007 USA

[7] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2021年 / 185卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Genetic polymorphisms; Breast cancer; Anti-Mullerian hormone; Case-control; AFRICAN-AMERICAN WOMEN; PREMENOPAUSAL WOMEN; ASSOCIATION; SUBTYPES;

D O I：

10.1007/s10549-020-05944-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Circulating anti-Mullerian hormone (AMH) levels are positively associated with time to menopause and breast cancer risk. We examined breast cancer associations with single nucleotide polymorphisms (SNPs) in theAMHgene or its receptor genes,ACVR1andAMHR2, among African American women. Methods In the AMBER consortium, we tested 65 candidate SNPs, and 1130 total variants, in or nearAMH,ACVR1, andAMHR2and breast cancer risk. Overall, 3649 cases and 4230 controls contributed to analyses. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer were calculated using multivariable logistic regression. Results After correction for multiple comparisons (false-discovery rate of 5%), there were no statistically significant associations with breast cancer risk. Without correction for multiple testing, four candidate SNPs inACVR1and one nearAMHwere associated with breast cancer risk. InACVR1, rs13395576[C] was associated with lower breast cancer risk overall (OR 0.84; 95% CI 0.72, 0.97) and for ER+ disease (OR 0.75; CI 0.62, 0.89) (p < 0.05). Rs1220110[A] and rs1220134[T] each had ORs of 0.89-0.90 for postmenopausal and ER+ breast cancer (p <= 0.03). Conversely, rs1682130[T] was associated with higher risk of ER+ breast cancer (OR 1.17; 95% CI 1.04, 1.32). NearAMH, rs6510652[T] had ORs of 0.85-0.90 for breast cancer overall and after menopause (p <= 0.02). Conclusions The present results, from a large study of African American women, provide limited support for an association between AMH-related polymorphisms and breast cancer risk and require replication in other studies.

引用

页码：469 / 478

页数：10

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