Reversible switching between epigenetic states in honeybee behavioral subcastes

被引：235

作者：

Herb, Brian R. ^{[2
,3
]}

Wolschin, Florian ^{[1
,4
]}

Hansen, Kasper D. ^{[2
,5
]}

Aryee, Martin J. ^{[2
,6
]}

Langmead, Ben ^{[5
]}

Irizarry, Rafael ^{[5
]}

Amdam, Gro V. ^{[1
,4
]}

Feinberg, Andrew P. ^{[2
,3
,5
,7
]}

机构：

[1] Norwegian Univ Life Sci, Dept Chem Biotechnol & Food Sci, As, Norway

[2] Johns Hopkins Univ, Sch Med, Ctr Epigenet, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[4] Arizona State Univ, Sch Life Sci, Tempe, AZ USA

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 10期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; DNA METHYLATION; ENCODES; MEMORY; SYSTEM; FAMILY;

D O I：

10.1038/nn.3218

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker and queen castes, but substantial differences between nurses and forager subcastes. Reverting foragers back to nurses reestablished methylation levels for a majority of genes and provides, to the best of our knowledge, the first evidence in any organism of reversible epigenetic changes associated with behavior.

引用

页码：1371 / 1373

页数：3

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