Zearalenone induces modifications of haematological and biochemical parameters in rats

K. Maaroufi, L. Chekir, E. E. Creppy, F. Ellouz and H. Bacha. Zearalenone induces modifications of haematological and biochemical parameters in rats. Toxicon 34, 535-540, 1996.-Zearalenone produced by the fungus Fusarium roseum causes important perturbations in the gestation cycle of the rat with hormonal disorders and infertility. In order to find out other eventual toxic effects, female rats were given intraperitoneally (i.p.) (1.5, 3 and 5 mg/kg) zearalenone in sterile olive oil. Forty-eight hours later, some blood parameters changed (hematocrit, MCV, the number of platelets and WBC) as well as some biochemical markers such as aminotransferases (ALT, AST), alkaline phosphatase (ALP), serum creatinine, bilirubin, indicating liver toxicity, and likely impairment of blood coagulation process. Copyright (C) 1996 Elsevier Science Ltd.