Antifungal steroidal glycosides from the Patagonian starfish Anasterias minuta:: Structure-activity correlations

被引：44

作者：

Chludil, HD

Seldes, AM

Maier, MS

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Nacl Patagonia, Fac Ciencias Nat, Dept Quim, RA-9000 Chubut, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期

关键词：

D O I：

10.1021/np010332x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sulfated steroidal hexaglycosides, anasterosides A (2) and B (3), along with the known versicoside A (1) have been isolated from the Patagonian starfish Anasterias minuta. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Compounds 1 and 2 and the synthetic pentaglycoside 1b derived from versicoside A showed antifungal activity against the plant pathogenic fungus Cladosporium cucumerinum. Desulfation of hexaglycoside 1 rendered a totally inactive, saponin.

引用

页码：153 / 157

页数：5

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