Antifungal steroidal glycosides from the Patagonian starfish Anasterias minuta:: Structure-activity correlations

被引：44
作者：
Chludil, HD
Seldes, AM
Maier, MS
机构：
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina
[2] Univ Nacl Patagonia, Fac Ciencias Nat, Dept Quim, RA-9000 Chubut, Argentina
来源：
JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期
关键词：
D O I：
10.1021/np010332x
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sulfated steroidal hexaglycosides, anasterosides A (2) and B (3), along with the known versicoside A (1) have been isolated from the Patagonian starfish Anasterias minuta. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Compounds 1 and 2 and the synthetic pentaglycoside 1b derived from versicoside A showed antifungal activity against the plant pathogenic fungus Cladosporium cucumerinum. Desulfation of hexaglycoside 1 rendered a totally inactive, saponin.
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页码：153 / 157
页数：5
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