Assessing miRNAs profile expression as a risk stratification biomarker in oral potentially malignant disorders: A systematic review

被引：27
作者：
El-Sakka, Haytham [1 ]
Kujan, Omar [1 ]
Farah, Camile S. [1 ,2 ]
机构：
[1] Univ Western Australia, UWA Dent Sch, 17 Monash Ave, Nedlands, WA 6009, Australia
[2] Univ Western Australia, UWA Dent Sch, Australian Ctr Oral Oncol Res & Educ, Nedlands, WA, Australia
来源：
ORAL ONCOLOGY | 2018年 / 77卷
关键词：
miRNAs; Oral potentially malignant disorders (OPMDs); Oral squamous cell carcinoma (OSCC); Systematic review; SQUAMOUS-CELL CARCINOMA; CD4(+) T-CELLS; LICHEN-PLANUS; MICRORNA EXPRESSION; TARGETING MICRORNAS; ALTERED EXPRESSION; PERIPHERAL-BLOOD; POOR-PROGNOSIS; PROGRESSION; LESIONS;
D O I：
10.1016/j.oraloncology.2017.11.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objectives: This paper aims to systematically review current findings on altered expression of miRNAs in OPMDs and whether they can be used as risk stratification biomarkers. Methods: Studies were collated after searching three different electronic databases: PubMed, Embase, Medline. Additional searches were carried out through cross checking the bibliographies of selected articles. After a thorough selection process made by two of the authors, 40 articles met the inclusion criteria and were included in the review. Studies were assessed and analysed in terms of how the candidate miRNA biomarkers were differentially expressed and validated. Results: The included studies examined the expression of miRNAs from human specimens (blood serum/plasma, saliva, tissue) as diagnostic or prognostic biomarkers in patients with OPMDs, some of which have been utilised as risk stratification biomarkers for malignant transformation and have showed promising findings. Conclusion: The current evidence to support or refute the prognostic utility of miRNAs in predicting cancer progression in OPMDs is equivocal. Further longitudinal prospective studies with solid study design are warranted.
引用
收藏
页码：57 / 82
页数：26
相关论文
共 70 条
[1]  
[Anonymous], CLIN ORAL INVESTIG
[2]  
[Anonymous], J ORAL PATHOL MED
[3]   Increased miRNA-146a and miRNA-155 expressions in oral lichen planus [J].
Arao, Telma Cristina ;
Sena Guimaraes, Andre Luiz ;
Batista de Paula, Alfredo Mauricio ;
Gomes, Carolina Cavalieri ;
Gomez, Ricardo Santiago .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2012, 304 (05) :371-375
[4]   Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available [J].
Benes, Vladimir ;
Castoldi, Mirco .
METHODS, 2010, 50 (04) :244-249
[5]   Relationship between microRNA expression levels and histopathological features of dysplasia in oral leukoplakia [J].
Brito, Joao A. R. ;
Gomes, Carolina C. ;
Guimaraes, Andre L. S. ;
Campos, Kelma ;
Gomez, Ricardo S. .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2014, 43 (03) :211-216
[6]   Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients [J].
Byun, J-S ;
Hong, S-H ;
Choi, J-K ;
Jung, J-K ;
Lee, H-J .
ORAL DISEASES, 2015, 21 (08) :987-993
[7]   Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma [J].
Cervigne, Nilva K. ;
Reis, Patricia P. ;
Machado, Jerry ;
Sadikovic, Bekim ;
Bradley, Grace ;
Naranjo Galloni, Natalie ;
Pintilie, Melania ;
Jurisica, Igor ;
Perez-Ordonez, Bayardo ;
Gilbert, Ralph ;
Gullane, Patrick ;
Irish, Jonathan ;
Kamel-Reid, Suzanne .
HUMAN MOLECULAR GENETICS, 2009, 18 (24) :4818-4829
[8]   Association between High miR-211 microRNA Expression and the Poor Prognosis of Oral Carcinoma [J].
Chang, K.-W. ;
Liu, C. J. ;
Chu, T.-H. ;
Cheng, H.-W. ;
Hung, P. S. ;
Hu, W. Y. ;
Lin, S. C. .
JOURNAL OF DENTAL RESEARCH, 2008, 87 (11) :1063-1068
[9]   Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer [J].
Chattopadhyay, Esita ;
Singh, Richa ;
Ray, Anindita ;
Roy, Roshni ;
De Sarkar, Navonil ;
Paul, Ranjan Rashmi ;
Pal, Mousumi ;
Aich, Ritesh ;
Roy, Bidyut .
SCIENTIFIC REPORTS, 2016, 6
[10]   Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers [J].
Chaturvedi, Anil K. ;
Anderson, William F. ;
Lortet-Tieulent, Joannie ;
Curado, Maria Paula ;
Ferlay, Jacques ;
Franceschi, Silvia ;
Rosenberg, Philip S. ;
Bray, Freddie ;
Gillison, Maura L. .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (36) :4550-4559
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