Gold-mediated selective cysteine modification of peptides using allenes

被引：35

作者：

Chan, Anna On-Yee ^{[1
,2
]}

Tsai, Johnson Lui-Lui ^{[1
,2
]}

Lo, Vanessa Kar-Yan ^{[1
,2
]}

Li, Gai-Li ^{[3
]}

Wong, Man-Kin ^{[3
]}

Che, Chi-Ming ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Chem, State Key Lab Synthet Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Inst Mol Technol Drug Discovery & Synth, Open Lab Chem Biol, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 14期

关键词：

CONVERGENT CHEMICAL-SYNTHESIS; POSTTRANSLATIONAL MODIFICATIONS; HIGHLY EFFICIENT; AQUEOUS-MEDIUM; ALLYLIC SELENOSULFIDE; RHODIUM CARBENOIDS; AMIDE SYNTHESIS; PROTEINS; LIGATION; CHEMISTRY;

D O I：

10.1039/c2cc38214h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach for selective modification of cysteine-containing peptides through gold-mediated oxidative allene-thiol coupling reaction in aqueous medium is developed.

引用

页码：1428 / 1430

页数：3