Investigation of Mycoplasma pneumoniae infection in pediatric population from 12,025 cases with respiratory infection

被引：36

作者：

He, Xiao-yan ^{[1
]}

Wang, Xing-bin ^{[1
]}

Zhang, Rong ^{[1
]}

Yuan, Zhao-jian ^{[1
]}

Tan, Jun-jie ^{[1
]}

Peng, Bin ^{[2
]}

Huang, Yi ^{[1
]}

Liu, En-mei ^{[3
]}

Fu, Zhou ^{[3
]}

Bao, Li-ming ^{[1
,4
,5
]}

Zou, Lin ^{[1
]}

机构：

[1] Chongqing Med Univ, Childrens Hosp,Chongqing Int Sci & Technol Cooper, Ctr Clin Mol Med,Key Lab Pediat Chongqing, Minist Educ,Key Lab Child Dev & Disorders,Ctr Chi, Chongqing 400014, Peoples R China

[2] Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Stat, Chongqing 400014, Peoples R China

[3] Chongqing Med Univ, Childrens Hosp, Dept Resp Med, Chongqing 400014, Peoples R China

[4] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Div Human Genet, Cincinnati, OH 45229 USA

[5] Univ Cincinnati, Coll Med, Cincinnati, OH 45229 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2013年 / 75卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mycoplasma pneumoniae; Pediatric; PCR; Serology; P1; gene; REAL-TIME PCR; SEQUENCE-BASED AMPLIFICATION; POLYMERASE-CHAIN-REACTION; CHLAMYDOPHILA-PNEUMONIAE; LEGIONELLA SPP; DIAGNOSIS; CHILDREN; SEROLOGY; IDENTIFICATION; SPECIMENS;

D O I：

10.1016/j.diagmicrobio.2012.08.027

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Although Mycoplasma pneumoniae (MP) is a major pathogen of primary atypical pneumonia in children, the clinical and laboratory characteristics of MP infection in large pediatric population are less reported. Here, we retrospectively analyzed 12,025 hospitalized children with respiratory infection by using serology and polymerase chain reaction (PCR) methods simultaneously. The results showed that 2433 (20.23%) children had MP infection, which mainly occurred in November to April. The presence of sore throat and pharyngitis was peculiar to MP infection. The positive percentage of MP-DNA was higher than that of MP-IgM in children aged <1 (P<0.0001) and 1-3 years (P<0.0001). Moreover, the positive rate of P1 gene, the key adhesion gene for MP infection, was higher in children with MP infection than in those with other pathogens (P < 0.0001). Our work provides the clinical information of children MP infection and highlights the superiority of PCR and potential usage of P1 as a diagnosis target for MP infection. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.

引用

页码：22 / 27

页数：6

共 38 条

[1] Evaluation of 12 commercial tests and the complement fixation test for Mycoplasma pneumoniae-specific immunoglobulin G (IgG) and IgM antibodies, with PCR used as the "gold standard" [J].