Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan

被引：27

作者：

Kawakita, Daisuke ^{[1
]}

Tada, Yuichiro ^{[2
]}

Imanishi, Yorihisa ^{[3
]}

Beppu, Shintaro ^{[1
]}

Tsukahara, Kiyoaki ^{[4
]}

Kano, Satoshi ^{[5
]}

Ozawa, Hiroyuki ^{[3
]}

Okami, Kenji ^{[6
]}

Sato, Yuichiro ^{[7
]}

Shimizu, Akira ^{[4
]}

Sato, Yukiko ^{[8
]}

Fushimi, Chihiro ^{[2
]}

Takase, Soichiro ^{[4
]}

Okada, Takuro ^{[2
]}

Sato, Hiroki ^{[4
]}

Otsuka, Kuninori ^{[3
]}

Watanabe, Yoshihiro ^{[3
]}

Sakai, Akihiro ^{[6
]}

Ebisumoto, Koji ^{[6
]}

Togashi, Takafumi ^{[7
]}

Ueki, Yushi ^{[7
]}

Ota, Hisayuki ^{[7
]}

Shimura, Tomotaka ^{[9
]}

Hanazawa, Toyoyuki ^{[10
]}

Murakami, Shingo ^{[1
]}

Nagao, Toshitaka ^{[9
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Otorhinolaryngol Head & Neck Surg, Nagoya, Aichi, Japan

[2] Int Univ Hlth & Welf Mita Hosp, Hlth & Welf Mita Hosp, Dept Head & Neck Oncol & Surg, Tokyo, Japan

[3] Keio Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Tokyo, Japan

[4] Tokyo Med Univ, Sch Med, Dept Otolaryngol, Tokyo, Japan

[5] Hokkaido Univ, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Sapporo, Hokkaido, Japan

[6] Tokai Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Isehara, Kanagawa, Japan

[7] Niigata Canc Ctr Hosp, Dept Head & Neck Surg, Niigata, Japan

[8] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Pathol, Tokyo, Japan

[9] Tokyo Med Univ, Sch Med, Dept Anat Pathol, Tokyo, Japan

[10] Chiba Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Chiba, Japan

来源：

ONCOTARGET | 2017年 / 8卷 / 01期

关键词：

salivary duct carcinoma; survival; mGPS; CRP; NLR; SQUAMOUS-CELL CARCINOMA; TO-LYMPHOCYTE RATIO; NASOPHARYNGEAL CARCINOMA; PROGNOSTIC-FACTORS; SYSTEMIC INFLAMMATION; PRETREATMENT NEUTROPHIL; POOR-PROGNOSIS; CANCER; SURVIVAL; HEAD;

D O I：

10.18632/oncotarget.13565

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models. High mGPS (>= 1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value<0.001). Additionally, high C-reactive protein (CRP) (>= 0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value= 0.001; 3-year PFS: 7.1% vs 31.1%, p-value<0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (>= 2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.

引用

页码：1083 / 1091

页数：9

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