The effect of dalteparin, a kind of low molecular weight heparin, on lung adenocarcinoma A549 cell line in vitro

被引：11
|
作者：
Chen, Xiaojun [1 ]
Xiao, Wei [1 ]
Qu, Xun [2 ]
Zhou, Shengyu [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Resp Dis, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Qilu Hosp, Inst Basic Med Sci, Jinan 250012, Shandong, Peoples R China
来源：
CANCER INVESTIGATION | 2008年 / 26卷 / 07期
关键词：
low molecular weight heparin; dalteparin; p21(WAF1); p27(KIP1); lung adenocarcinoma;
D O I：
10.1080/07357900801935631
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The beneficial effects of unfractionated heparin and low molecular weight heparin on cancer progression have been reported. In the study, the effect of dalteparin on pulmonary adenocarcinoma A549 cell line was observed in vitro. Our experiments revealed that: (1) dalteparin can inhibit the cell viability dose-dependently and time-dependently; (2) dalteparin can arrest the A549 cells in G(1) phase and induce them to early apoptosis; (3) dalteparin exerts its effects through p21(WAF1) and p27(KIP1) proteins; and (4) the changes of p21(WAF1) and p27(KIP1) proteins caused by dalteparin occurred at posttranscriptional levels.
引用
收藏
页码：718 / 724
页数：7
相关论文
共 50 条
  • [41] Apoptotic effect of cordycepin on A549 human lung cancer cell line
    Tuli, Hardeep Singh
    Kumar, Gaurav
    Sandhu, Sardul Singh
    Sharma, Anil Kumar
    Kashyap, Dharmbir
    TURKISH JOURNAL OF BIOLOGY, 2015, 39 (02) : 306 - 311
  • [42] The effect of heparin and low molecular weight heparin on osteoblastogenesis in vitro.
    Bhandari, M
    Hirsh, J
    Weitz, JI
    Shaughnessy, SG
    BLOOD, 1998, 92 (10) : 358A - 358A
  • [43] Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo
    Luo, Gang
    Guan, Xiaoling
    Zhou, Liming
    CANCER BIOLOGY & THERAPY, 2008, 7 (06) : 970 - 977
  • [44] Effect of juglone on cell cycle arrest of human lung adenocarcinoma A549 cells
    Xiang, Zou
    Zhong-Yuan, Qu
    Ling-Sheng, Kong
    Yu-Bin, Ji
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 291P - 291P
  • [45] Effect of a 630 nm light on vasculogenic mimicry in A549 lung adenocarcinoma cells in vitro
    Lin, Cunzhi
    Wang, Jingyu
    Ma, Yijiang
    Han, Weizhong
    Cao, Yiwei
    Shao, Mingju
    Cui, Shichao
    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2023, 44
  • [46] The effect of elemene on lung adenocarcinoma A549 cell radiosensitivity and elucidation of its mechanism
    Zou, Kun
    Liu, Caigang
    Zhang, Zhuo
    Zou, Lijuan
    CLINICS, 2015, 70 (08) : 556 - 562
  • [47] Molecular mechanism of trifluoperazine induces apoptosis in human A549 lung adenocarcinoma cell lines
    Chen, Qingyong
    Wu, Li Jun
    Wu, Yu Quan
    Lu, Guo Hua
    Jiang, Zhong Yong
    Zhan, Jian Wei
    Jie, Yan
    Zhou, Jian Ying
    MOLECULAR MEDICINE REPORTS, 2009, 2 (05) : 811 - 817
  • [48] Thromboprophylaxis with low molecular weight heparin (dalteparin) compared with unfractionated heparin in pregnancy.
    Kaaja, R
    Pettilä, V
    Leinonen, P
    Ikkala, E
    BLOOD, 1998, 92 (10) : 360A - 360A
  • [49] Low-molecular-weight heparin (dalteparin) demonstrated a weaker effect on rat bone metabolism compared with heparin
    Nishiyama, M
    Itoh, F
    Ujiie, A
    JAPANESE JOURNAL OF PHARMACOLOGY, 1997, 74 (01): : 59 - 68
  • [50] Anticoagulation with low-molecular-weight heparin dalteparin in atrial fibrillation
    Bechtold, H
    Sawitzki, H
    Gunzenhauser, D
    Janssen, D
    EUROPEAN HEART JOURNAL, 2000, 21 : 8 - 8
12345