The effect of dalteparin, a kind of low molecular weight heparin, on lung adenocarcinoma A549 cell line in vitro

被引：11
|
作者：
Chen, Xiaojun [1 ]
Xiao, Wei [1 ]
Qu, Xun [2 ]
Zhou, Shengyu [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Resp Dis, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Qilu Hosp, Inst Basic Med Sci, Jinan 250012, Shandong, Peoples R China
来源：
CANCER INVESTIGATION | 2008年 / 26卷 / 07期
关键词：
low molecular weight heparin; dalteparin; p21(WAF1); p27(KIP1); lung adenocarcinoma;
D O I：
10.1080/07357900801935631
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The beneficial effects of unfractionated heparin and low molecular weight heparin on cancer progression have been reported. In the study, the effect of dalteparin on pulmonary adenocarcinoma A549 cell line was observed in vitro. Our experiments revealed that: (1) dalteparin can inhibit the cell viability dose-dependently and time-dependently; (2) dalteparin can arrest the A549 cells in G(1) phase and induce them to early apoptosis; (3) dalteparin exerts its effects through p21(WAF1) and p27(KIP1) proteins; and (4) the changes of p21(WAF1) and p27(KIP1) proteins caused by dalteparin occurred at posttranscriptional levels.
引用
收藏
页码：718 / 724
页数：7
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