Molecular systems biology and control

被引:106
作者
Sontag, ED [1 ]
机构
[1] Rutgers State Univ, Dept Math, New Brunswick, NJ 08903 USA
[2] Rutgers State Univ, BioMaPS Inst Quantitat Biol, New Brunswick, NJ 08903 USA
关键词
dynamics and control in biological networks; molecular systems biology; monotone systems;
D O I
10.3166/ejc.11.396-435
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
This paper, prepared for a tutorial at the 2005 IEEE Conference on Decision and Control, presents an introduction to molecular systems biology and some associated problems in control theory. It provides an introduction to basic biological concepts, describes several questions in dynamics and control that arise in the field, and argues that new theoretical problems arise naturally in this context. A final section focuses on the combined use of graph-theoretic, qualitative knowledge about monotone building-blocks and steady-state step responses for components.
引用
收藏
页码:396 / 435
页数:40
相关论文
共 103 条
[1]  
AGNELI D, 2004, OPTIMAL CONTROL STAB, P135
[2]   The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster [J].
Albert, R ;
Othmer, HG .
JOURNAL OF THEORETICAL BIOLOGY, 2003, 223 (01) :1-18
[3]  
Alberts B., 2002, Molecular Biology of The Cell, V4th
[4]   GLOBAL STABILITY-CRITERION FOR SIMPLE CONTROL LOOPS [J].
ALLWRIGHT, DJ .
JOURNAL OF MATHEMATICAL BIOLOGY, 1977, 4 (04) :363-373
[5]   Robustness in bacterial chemotaxis [J].
Alon, U ;
Surette, MG ;
Barkai, N ;
Leibler, S .
NATURE, 1999, 397 (6715) :168-171
[6]   Inference of signaling and gene regulatory networks by steady-state perturbation experiments: structure and accuracy [J].
Andrec, M ;
Kholodenko, BN ;
Levy, RM ;
Sontag, E .
JOURNAL OF THEORETICAL BIOLOGY, 2005, 232 (03) :427-441
[7]   Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feed back systems [J].
Angeli, D ;
Ferrell, JE ;
Sontag, ED .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) :1822-1827
[8]   An analysis of a circadian model using the small-gain approach to monotone systems [J].
Angeli, D ;
Sontag, ED .
2004 43RD IEEE CONFERENCE ON DECISION AND CONTROL (CDC), VOLS 1-5, 2004, :575-578
[9]   Remarks on monotonicity and convergence in chemical reaction networks [J].
Angeli, D ;
De Leeneheer, P ;
Sontag, ED .
2004 43RD IEEE CONFERENCE ON DECISION AND CONTROL (CDC), VOLS 1-5, 2004, :243-248
[10]   Multi-stability in monotone input/output systems [J].
Angeli, D ;
Sontag, ED .
SYSTEMS & CONTROL LETTERS, 2004, 51 (3-4) :185-202