Signal transduction in transgenic mouse models of human breast cancer - Implications for human breast cancer

被引：34
|
作者：
Marcotte, Richard [1 ,2 ]
Muller, William J. [1 ,2 ,3 ]
机构：
[1] Royal Victoria Hosp, Mol Oncol Grp, Montreal, PQ H3A 1A1, Canada
[2] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[3] McGill Univ, Dept Med, Montreal, PQ, Canada
来源：
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2008年 / 13卷 / 03期
关键词：
ErbB2; PyV MT; transgenic; MMTV; breast cancer;
D O I：
10.1007/s10911-008-9087-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The advent of genetically engineered mouse models (GEMs) of human breast cancer, have provided important insight into molecular basis or human breast cancer. This review will focus on two of the most extensively studied mouse models for human breast cancer involving mammary gland specific expression of the polyoma middle T (PyV MT) antigen and of the ErbB2. In addition, this review will discuss past and recent advances in understanding relative contribution of the signaling pathways in tumor induction and metastasis by these potent mammary oncogenes.
引用
收藏
页码：323 / 335
页数：13
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