Drug Testing in the Neonate

被引:35
作者
Cotten, Steven W. [1 ]
机构
[1] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27514 USA
关键词
Neonate; Drugs of abuse; Meconium; Pregnancy; Newborn; PRENATAL MARIJUANA EXPOSURE; ACID ETHYL-ESTERS; COCAINE EXPOSURE; ABSTINENCE SYNDROME; SUBSTANCE-USE; MAJOR METABOLITES; CANNABIS EXPOSURE; AMNIOTIC-FLUID; MECONIUM; PREGNANCY;
D O I
10.1016/j.cll.2012.06.008
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Drug testing in newborns comes with analytical, therapeutic, and legal issues, and interpretation of results may be left to physicians, nurses, or social services workers. The unique analytical and legal caveats pose a variety of challenges and therapeutic issues. Positive drug screening results can allow for proper medical management of withdrawal symptoms for certain drug classes. Legal implications and involvement of social services for assessment of child safety surround positive urine or meconium drug samples. Because laboratory results can potentially remove newborns from their biological parents, the caveats and limitations of drug testing in this population are of utmost importance.
引用
收藏
页码:449 / +
页数:19
相关论文
共 66 条
[1]   Preadolescent behavior problems after prenatal cocaine exposure: Relationship between teacher and caretaker ratings (Maternal Lifestyle Study) [J].
Bada, Henrietta S. ;
Bann, Carla M. ;
Bauer, Charles R. ;
Shankaran, Seetha ;
Lester, Barry ;
LaGasse, Linda ;
Hammond, Jane ;
Whitaker, Toni ;
Das, Abhik ;
Tan, Sylvia ;
Higgins, Rosemary .
NEUROTOXICOLOGY AND TERATOLOGY, 2011, 33 (01) :78-87
[2]   Gestational cocaine exposure and intrauterine growth: Maternal lifestyle study [J].
Bada, HS ;
Das, A ;
Bauer, CR ;
Shankaran, S ;
Lester, B ;
Wright, LL ;
Verter, J ;
Smeriglio, VL ;
Finnegan, LP ;
Maza, PL .
OBSTETRICS AND GYNECOLOGY, 2002, 100 (05) :916-924
[3]   Estimated effects of in utero cocaine exposure on language development through early adolescence [J].
Bandstra, Emmalee S. ;
Morrow, Connie E. ;
Accornero, Veronica H. ;
Mansoor, Elana ;
Xue, Lihua ;
Anthony, James C. .
NEUROTOXICOLOGY AND TERATOLOGY, 2011, 33 (01) :25-35
[4]   Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse [J].
Bar-Oz, B ;
Klein, J ;
Karaskov, T ;
Koren, G .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2003, 88 (02) :F98-F100
[5]   The Maternal Lifestyle Study: Drug exposure during pregnancy and short-term maternal outcomes [J].
Bauer, CR ;
Shankaran, S ;
Bada, HS ;
Lester, B ;
Wright, LL ;
Krause-Steinrauf, H ;
Smeriglio, VL ;
Finnegan, LP ;
Maza, PL ;
Verter, J .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (03) :487-495
[6]   Fatty acid ethyl esters: Toxic non-oxidative metabolites of ethanol and markers of ethanol intake [J].
Best, CA ;
Laposata, M .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2003, 8 :E202-E217
[7]   Oral Fluid Testing for Drugs of Abuse [J].
Bosker, Wendy M. ;
Huestis, Marilyn A. .
CLINICAL CHEMISTRY, 2009, 55 (11) :1910-1931
[8]   ANALYSIS OF MECONIUM FOR COCAINE IN NEONATES [J].
BROWNE, SP ;
TEBBETT, IR ;
MOORE, CM ;
DUSICK, A ;
COVERT, R ;
YEE, GT .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 575 (01) :158-161
[9]  
CASANOVA OQ, 1994, ARCH PATHOL LAB MED, V118, P988
[10]   Placental handling of fatty acid ethyl esters: Perfusion and subcellular studies [J].
Chan, D ;
Knie, B ;
Boskovic, R ;
Koren, G .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 310 (01) :75-82