Responsive hairpin DNA aptamer switch to program the strand displacement reaction for the enhanced electrochemical assay of ATP

被引：16

作者：

Wang, Li ^{[1
]}

Fang, Li ^{[1
]}

Liu, Shufeng ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Key Lab Sensor Anal Tumor Marker, Minist Educ, Zhengzhou 266042, Shandong, Peoples R China

来源：

ANALYST | 2015年 / 140卷 / 17期

基金：

中国国家自然科学基金;

关键词：

SURFACE HYBRIDIZATION ASSAY; SIGNAL AMPLIFICATION; TOEHOLD ACTIVATION; EXONUCLEASE III; APTASENSOR; SENSORS; BIOSENSOR; SELECTION; PROTEIN; NANOPARTICLES;

D O I：

10.1039/c5an00725a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A responsive hairpin DNA aptamer switch was ingeniously designed for enzyme-free, sensitive and selective electrochemical detection of ATP. It takes full advantage of the target-triggered liberation effect of the toehold region and the concomitant proximity effect with the branch-migration region to execute the toehold-mediated strand displacement reaction on the electrode surface.

引用

页码：5877 / 5880

页数：4

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