Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

被引：164

作者：

Bolduc, Francois V. ^{[1
,3
]}

Bell, Kimberly ^{[3
]}

Cox, Hilary ^{[3
]}

Broadie, Kendal S. ^{[2
]}

Tully, Tim ^{[1
,3
,4
]}

机构：

[1] Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] Vanderbilt Univ, Nashville, TN 37235 USA

[3] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[4] Dart Neurosci LLC, San Diego, CA 92121 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 10期

关键词：

D O I：

10.1038/nn.2175

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.

引用

页码：1143 / 1145

页数：3

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