Prenatal morphine exposure decreases susceptibility of adult male rat offspring to bicuculline seizures

被引：20
作者：
Schindler, CJ
Slamberová, R
Vathy, I
机构：
[1] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10461 USA
来源：
BRAIN RESEARCH | 2001年 / 922卷 / 02期
关键词：
epilepsy; prenatal drug exposure; opiate; androgen; testosterone;
D O I：
10.1016/S0006-8993(01)03183-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The purpose of this study was to investigate the effect of prenatal exposure to morphine (5-10 mg/kg twice daily on days 11-18 of gestation) on bicuculline seizure susceptibility and to examine the interaction of prenatal morphine exposure and hormonal background in adult male rats. The data demonstrate that prenatal morphine exposure does not affect clonic but decreases susceptibility to tonic-clonic bicuculline seizures in intact male rats. Thus, the present data support our previous work demonstrating alterations in seizure susceptibility of adult morphine-exposed animals. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：305 / 309
页数：5
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